Cigarette smoking increases the risk of pancreatic calcification in late-onset but not early-onset idiopathic chronic pancreatitis
Cigarette smoking increases the risk of pancreatic calcification in late-onset but not early-onset idiopathic chronic pancreatitis
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DOI：
10.1097/00006676-200008000-00002
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发表时间：
2000-08-01
期刊：
影响因子：
2.9
通讯作者：
DiMagno, EP
中科院分区：
文献类型：
--
作者：
Imoto, M;DiMagno, EP
吸烟和酒精引起的胰腺炎之间存在联系。我们确定吸烟是否会影响特发性慢性胰腺炎的胰腺钙化和功能不全的进程。对1976年至1982年诊断的24例早期和42例迟发性特发性慢性胰腺炎患者的病历进行了分析，然后前瞻性随访至1985年。在钙化或功能不全或末次随访前，吸烟等于>5包-年。早发性和晚发性特发性慢性胰腺炎发病后的平均随访时间分别为27年和13年。两组的钙化发生率分别为58%和43%。在早发性特发性慢性胰腺炎中，吸烟者和非吸烟者发生钙化的比率和频率相似（58%）。在迟发性特发性慢性胰腺炎中，吸烟者比非吸烟者更快（p< 0.001）和更频繁地（83% vs. 13%，p < 0.001）发生胰腺钙化。吸烟与胰腺钙化之间的关系与性别、体重指数、外分泌或内分泌功能不全无关。吸烟不影响外分泌或内分泌功能不全的发展。吸烟增加晚发性慢性胰腺炎胰腺钙化的风险，但不增加早发性慢性胰腺炎的风险。这些数据支持鼓励戒烟的慢性胰腺炎。
An association exists between cigarette smoking and pancreatitis owing to alcohol. We determined whether cigarette smoking affected the course of pancreatic calcification and insufficiency in idiopathic chronic pancreatitis. Medical records were analyzed of 24 persons with early- and 42 with late-onset idiopathic chronic pancreatitis who were diagnosed between 1976 and 1982 and then followed prospectively until 1985. Smoking equaled >5 pack-years before calcification or insufficiency or last follow-up. Mean follow-up after onset of chronic pancreatitis was 27 and 13 years in early- and late-onset idiopathic chronic pancreatitis, respectively. Incidence of calcification in the two groups was 58 and 43%, respectively. In early-onset idiopathic chronic pancreatitis, smokers and nonsmokers developed calcification at a similar rate and frequency (58%). In late-onset idiopathic chronic pancreatitis, smokers developed pancreatic calcifications faster (p< 0.001) and more frequently (83 vs. 13%, p < 0.001) than nonsmokers. The association between smoking and pancreatic calcification was independent of gender, body mass index, and exocrine or endocrine insufficiency. Smoking did not affect development of exocrine or endocrine insufficiency. Cigarette smoking increases the risk of pancreatic calcification of late- but not of early-onset idiopathic chronic pancreatitis. These data support encouraging cessation of smoking in chronic pancreatitis.