Pumps, aqueducts, and drought management: vascular physiology in vascular cognitive impairment.
Pumps, aqueducts, and drought management: vascular physiology in vascular cognitive impairment.
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泵，渡槽和干旱管理：血管认知障碍的血管生理。
DOI：
10.1161/strokeaha.110.595645
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发表时间：
2011-01
期刊：
影响因子：
8.3
通讯作者：
Lazar RM
中科院分区：
文献类型：
--
作者：
Marshall RS;Lazar RM
血管性认知功能障碍传统上被定义为结构性病理学-梗死的积累-导致进行性认知能力下降。然而，最近的证据表明，认知功能障碍可能是独立介导的血流动力学功能障碍，包括全球和半球灌注不足和改变脑血流调节。在这篇综述中，我们研究了大血管疾病、心力衰竭和微血管疾病中血流动力学损害对认知功能障碍的影响。如果存在血管性认知障碍的血流动力学成分，则可以合理地预期，提出用于纠正受损血管生理学的治疗也可以治疗认知功能障碍。
Vascular cognitive impairment has been traditionally defined by structural pathology – an accumulation of infarcts -- leading to progressive cognitive decline. Recent evidence, however, suggests that cognitive impairment may be independently mediated by hemodynamic dysfunction including global and hemispheral hypoperfusion and altered cerebral blood flow regulation. In this review we examine evidence for the contribution of hemodynamic impairment to cognitive dysfunction in the setting of large vessel disease, cardiac failure, and microvascular disease. If there is a hemodynamic component of vascular cognitive impairment, then treatments proposed to correct impaired vascular physiology may reasonably be expected to treat the cognitive dysfunction as well.