Oxytocin and 'social hyperthermia': Interaction with β3-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice
Oxytocin and 'social hyperthermia': Interaction with β3-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice
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DOI：
10.1016/j.yhbeh.2021.104981
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发表时间：
2021-04-18
影响因子：
3.5
通讯作者：
Jaime, Mark
中科院分区：
文献类型：
--
作者：
Harshaw, Christopher;Lanzkowsky, Jessica;Jaime, Mark
催产素（OT）是能量稳态多个方面的关键调节因子，包括棕色脂肪组织（BAT）产热。然而，目前尚不清楚，如果有的话，OT的体温调节和代谢作用对成年啮齿动物的社会行为表现有什么影响。在这里，我们研究了OT受体（OTR）和？肾上腺素能受体(？3AR)与通常伴随社交互动的体温升高（即社交热疗；SH）以及SH是否与成年小鼠的社交行为表达有关。具体来说，我们研究了通过外周注射L-368,899 （10 mg/kg）对C57BL/6J小鼠的OTR拮抗作用如何影响其社会行为的表达。3AR，已知介导应激诱导BAT产热的受体。在药物治疗和30分钟的延迟后，小鼠与不熟悉的同性同种进行10分钟的社会互动测试。我们假设OTR和？3AR/BAT相互作用影响社会互动中的行为，至少在一定程度上，OT对依赖于OT的社会行为有影响？3AR/BAT的热效应。我们发现otr介导的温度升高在很大程度上是小鼠社交互动中SH的原因。虽然不是通过？依赖3ar的BAT产热。此外，我们的研究结果揭示了OTR、？3AR，社会热疗和特定社会行为的表现，SH与焦虑和/或警惕相关行为最密切相关？也就是说，敌对或干扰亲密的、非敌对的社会行为的开始的行为。
Oxytocin (OT) is a critical regulator of multiple facets of energy homeostasis, including brown adipose tissue (BAT) thermogenesis. Nevertheless, it is unclear what, if any, consequence the thermoregulatory and metabolic effects of OT have for the display of social behavior in adult rodents. Here, we examine the contribution of the OT receptor (OTR) and ?3 adrenergic receptor (?3AR) to the increase in body temperature that typically accompanies social interaction (i.e., social hyperthermia; SH) and whether SH relates to the expression of social behavior in adult mice. Specifically, we examined how OTR antagonism via peripheral injection of L-368,899 (10 mg/kg) affects the expression of social behavior in C57BL/6J mice, in the presence of active/agonized versus antagonized ?3AR, the receptor known to mediate stress-induced BAT thermogenesis. After drug treatment and a 30 min delay, mice were provided a 10 min social interaction test with an unfamiliar, same-sex conspecific. We hypothesized that OTR and ?3AR/BAT interact to influence behavior during social interaction, with at least some effects of OT on social behavior dependent upon OT?s thermal effects via ?3AR/BAT. We found that OTRmediated temperature elevation is largely responsible for SH during social interaction in mice?albeit not substantially via ?3AR-dependent BAT thermogenesis. Further, our results reveal a complex relationship between OTR, ?3AR, social hyperthermia and the display of specific social behaviors, with SH most closely associated with anxiety and/or vigilance-related behaviors?that is, behaviors that antagonize or interfere with the initiation of close, non-agonistic social behavior.