Theranos phenomenon: promises and fallacies
Theranos phenomenon: promises and fallacies
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Theranos 现象：承诺与谬误
DOI：
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发表时间：
2015
影响因子：
6.8
通讯作者：
E. Diamandis
中科院分区：
文献类型：
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作者：
E. Diamandis
摘要 最近，诊断技术、基因组学等方面的惊人进展为对无症状个体进行广泛检测提供了前所未有的机会，希望这种检测能够揭示早期疾病迹象，从而采取预防或更有效的治疗措施。特别是，商业组织 Theranos 承诺通过在商业网点以低价提供多分析物测试来彻底改变诊断，从而挑战当前有针对性的集中诊断测试模式。在本文中，我分析了 Theranos 的技术及其承诺，并将这些信息与当前使用的技术进行对比，以表明该公司的大部分说法都被夸大了。虽然这项技术是否会彻底改变诊断还有待观察，但在这篇意见文件中，我也提请注意相关问题，例如自我测试和自我解释结果、过度测试、过度诊断和过度治疗及其相关危害。随着公众每天都受到与健康相关的新的革命性进展的轰炸，是时候通过解释相关的可能危害来平衡看似明显的巨大收益的热情了。
Abstract Recently, spectacular advances in diagnostic technologies, genomics, etc. offer unprecedented opportunities for widespread testing of asymptomatic individuals, in the hope that this testing will unravel early disease signs which could lead to preventative or more effective therapeutic measures. In particular, one commercial organization, Theranos, promises to revolutionize diagnostics by offering multi-analyte testing at low prices in commercial outlets, thus challenging the current paradigm of targeted and centralized diagnostic testing. In this paper, I analyze the Theranos technology and their promises, and contrast this information with the currently used technologies, to show that most of the company’s claims are exaggerated. While it remains to be seen if this technology will revolutionize diagnostics, in this Opinion Paper, I also draw attention of associated issues, such as self-testing and self-interpretation of results, over-testing, over-diagnosis and over-treatment, along with their associated harms. As the public is bombarded daily with new and revolutionary health-related advances, it is time to balance the enthusiasm of the seemingly obvious huge gains, by also explaining the associated possible harms.
影响因子：
158.5
作者：
FISHER, B;REDMOND, C;SIDOROVICH, L
通讯作者：
SIDOROVICH, L
DOI：
10.1783/147118909788707887
发表时间：
2009-04
影响因子：
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作者：
U. Menon;A. Gentry-Maharaj;Rachel Hallett;Andy Ryan;M. Burnell;Aarti Sharma;S. Lewis;S. Davies-S.-Davi
通讯作者：
U. Menon;A. Gentry-Maharaj;Rachel Hallett;Andy Ryan;M. Burnell;Aarti Sharma;S. Lewis;S. Davies-S.-Davi