Cerebral blood flow in hypertensive patients - An initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks
Cerebral blood flow in hypertensive patients - An initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks
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DOI：
10.1161/01.hyp.31.6.1216
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发表时间：
1998-06-01
期刊：
影响因子：
8.3
通讯作者：
Manuck, SB
中科院分区：
文献类型：
--
作者：
Jennings, JR;Muldoon, MF;Manuck, SB
我们询问与原发性高血压相关的脑血管系统改变是否会抑制或改变局部脑血流（rCBF）对认知工作的反应。在工作记忆任务、记忆广度任务和两个知觉控制任务中，用[O-15]水正电子发射断层扫描评估相对rCBF。未服药的高血压患者和对照组受试者在两项记忆任务中的rCBF反应存在差异。高血压患者右半球区域rCBF反应相对减弱，并伴有左脑皮层相应区域的代偿性激活。原发性高血压似乎选择性地影响部分大脑皮层的循环储备，并继发性地诱导其他皮层区域的募集来处理某些任务。
We asked whether the altered cerebral vasculature associated with essential hypertension might dampen or redirect the regional cerebral blood flow (rCBF) response to cognitive work. Relative rCBF was assessed with [O-15]water positron emission tomography during a working memory task, a memory span task, and two perceptual control tasks. Unmedicated hypertensive patients and control subjects differed in rCBF response during both memory tasks. Hypertensives showed relatively diminished rCBF responses in right hemisphere areas combined with compensatory activation of homologous areas in the left cerebral cortex. Essential hypertension appears to selectively influence the circulatory reserve of portions of cerebral cortex and secondarily induce recruitment of other cortical areas to process certain tasks.