The Epithelial Cell Glycocalyx in Ocular Surface Infection.
The Epithelial Cell Glycocalyx in Ocular Surface Infection.
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DOI：
10.3389/fimmu.2021.729260
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发表时间：
2021
影响因子：
7.3
通讯作者：
AbuSamra DB
中科院分区：
文献类型：
--
作者：
Argüeso P;Woodward AM;AbuSamra DB
糖萼是位于眼表上皮细胞与外部环境之间的界面处的跨细胞屏障的主要成分。该屏障从质膜延伸至500 nm，并伸入到浸泡眼睛表面的泪液中。在稳态条件下，糖萼中的防御分子，如跨膜粘蛋白，抵抗感染。然而，许多病原微生物已经进化到利用糖萼的组分以获得上皮细胞的通路并因此施加有害作用。本文综述了眼表上皮糖萼与细菌、病毒、真菌和寄生虫感染的关系。此外，它提出了一些正在进行的争议周围的上皮糖萼眼部感染性疾病的功能相关性。
The glycocalyx is the main component of the transcellular barrier located at the interface between the ocular surface epithelia and the external environment. This barrier extends up to 500 nm from the plasma membrane and projects into the tear fluid bathing the surface of the eye. Under homeostatic conditions, defense molecules in the glycocalyx, such as transmembrane mucins, resist infection. However, many pathogenic microorganisms have evolved to exploit components of the glycocalyx in order to gain access to epithelial cells and consequently exert deleterious effects. This manuscript reviews the implications of the ocular surface epithelial glycocalyx to bacterial, viral, fungal and parasitic infection. Moreover, it presents some ongoing controversies surrounding the functional relevance of the epithelial glycocalyx to ocular infectious disease.