Biodegradation and bioresorption of calcium phosphate ceramics
Biodegradation and bioresorption of calcium phosphate ceramics
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DOI：
10.1016/0267-6605(93)90049-d
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发表时间：
1993-01-01
期刊：
影响因子：
--
通讯作者：
Legeros, Racquel Z.
中科院分区：
文献类型：
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作者：
Legeros, Racquel Z.
几种磷酸钙（Ca-P）材料用于骨修复、增强、替代和作为金属植入物的涂层，在许多牙科和医疗应用中已获得临床认可。这些Ca-P材料可以是合成的或天然的，可以以不同的物理形式（致密或大孔、颗粒或块）获得，并且大量用作金属和非金属基底的涂层或用作复合材料、水泥和生物活性玻璃中的组分。磷酸钙材料的生物降解或生物再吸收意味着体外或体内细胞介导的降解。生物降解或生物再吸收过程中的细胞活性发生在酸性介质中;因此影响Ca-P材料的溶解度或溶解程度（这反过来又取决于物理化学性质）的因素很重要。由于从溶解的Ca-P材料释放钙和磷酸根离子而导致的微环境的富集影响细胞的增殖和活性。钙离子和磷酸根离子浓度的增加促进了类似于骨磷灰石的碳酸磷灰石的形成。本文的目的是讨论钙磷材料的生物降解或生物再吸收的过程中，这些材料的物理化学性质和所涉及的现象，包括在这些材料的表面和附近的碳酸盐磷灰石的形成。这种现象似乎与材料的生物活性以及此类材料直接附着于骨并形成独特的强材料-骨界面的能力有关。
The use of several calcium phosphate (Ca-P) materials for bone repair, augmentation, substitution and as coatings on metal implants has gained clinical acceptance in many dental and medical applications. These Ca-P materials may be of synthetic or natural origin, available in different physical forms (dense or macroporous, particles or blocks) and are used in bulk as coatings for metallic and non-metallic substrates or as components in composites, cements and bioactive glasses. Biodegradation or bioresorption of calcium phosphate materials implies cell-mediated degradation in vitro or in vivo. Cellular activity during biodegradation or bioresorption occurs in acid media; thus the factors affecting the solubility or the extent of dissolution (which in turn depends on the physico-chemical properties) of the Ca-P materials are important. Enrichment of the microenvironment due to the release of calcium and phosphate ions from the dissolving Ca-P materials affects the proliferation and activities of the cells. The increase in the concentrations of the calcium and phosphate ions promotes the formation of carbonate apatite which are similar to the bone apatite. The purpose of this invited paper is to discuss the processes of biodegradation or bioresorption of Ca-P materials in terms of the physico-chemical properties of these materials and the phenomena involved including the formation of carbonate apatite on the surfaces and in the vicinity of these materials. This phenomenon appears to be related to the bioactivity of the material and the ability of such materials to directly attach to bone and to form a uniquely strong material-bone interface.