The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin-low-density lipoprotein.
The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin-low-density lipoprotein.
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DOI：
10.1007/s00380-014-0549-9
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发表时间：
2015-11
影响因子：
1.5
通讯作者：
Hasegawa K
中科院分区：
文献类型：
--
作者：
Komiyama M;Wada H;Ura S;Yamakage H;Satoh-Asahara N;Shimada S;Akao M;Koyama H;Kono K;Shimatsu A;Takahashi Y;Hasegawa K
虽然戒烟后心血管风险降低，但体重往往在戒烟后的早期增加。我们此前曾报道，低密度脂蛋白1-抗胰蛋白酶-低密度脂蛋白复合体(AT-α)--一种氧化修饰的低密度脂蛋白，可加速动脉粥样硬化--在目前的吸烟者中水平很高，戒烟后该水平迅速下降。然而，戒烟后体重增加对这一心血管标志物的影响尚不清楚。对183例成功戒烟的门诊患者(男134例，女49例)，用酶联免疫吸附试验测定了血清AT-LDL水平。对于所有成功戒烟的人来说，在第一次检查后12周，身体质量指数(BMI)显著增加(P<0.01)。在BMI升幅小于中位数的患者中，发现血清AT-LDL值显著下降(P<0.01)，而在BMI升幅大于中位数的患者中，AT-LDL值无显著变化。研究结果提示，戒烟后血清AT-LDL水平的下降受戒烟后体重增加的影响。
Although cardiovascular risks decrease after quitting smoking, body weight often increases in the early period after smoking cessation. We have previously reported that the serum level of the α1-antitrypsin–low-density lipoprotein complex (AT–LDL)—an oxidatively modified low-density lipoprotein that accelerates atherosclerosis—is high in current smokers, and that the level rapidly decreases after smoking cessation. However, the effects of weight gain after smoking cessation on this cardiovascular marker are unknown. In 183 outpatients (134 males, 49 females) who had successfully quit smoking, serum AT–LDL levels were measured using an enzyme-linked immunosorbent assay. For all persons who had successfully quit smoking, body mass index (BMI) significantly increased 12 weeks after the first examination (p < 0.01). Among patients with a BMI increase smaller than the median, a significant decrease (p < 0.01) in serum AT–LDL values was found, but no significant changes in serum AT–LDL values were found in patients with a BMI increase greater than the median. The findings suggest that the decrease in serum AT–LDL levels after quitting smoking is influenced by weight gain after smoking cessation.