Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review.
Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review.
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急性肺栓塞的诊断血液生物标志物：系统评价。
DOI：
10.3390/diagnostics13132301
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发表时间：
2023-07-06
期刊：
影响因子：
3.6
通讯作者：
Hansen, John-Bjarne
中科院分区：
文献类型：
--
作者：
Wikan, Varin Eiriksdatter;Tondel, Birgitte Gladso;Morelli, Vania Maris;Brodin, Ellen Elisabeth;Braekkan, Sigrid Kufaas;Hansen, John-Bjarne
(1)背景：当前急性肺栓塞（PE）的诊断算法与CT肺血管造影（CTPA）的过度使用有关。额外的高度特异性血液检测可能会降低需要 CTPA 的疑似肺栓塞患者比例。目的是总结急诊室疑似急性肺栓塞患者生物标志物诊断性能的文献。 (2)方法：检索1995年至今的Medline和Embase数据库。研究选择过程、数据提取和偏倚风险评估由两名评审员进行。资格标准接受除D-二聚体以外的所有血液生物标志物，并使用CTPA作为参考标准。进行了定性数据合成。 (3)结果：在8448条已识别记录中，仅包含6条。鉴定出八种血液生物标志物，其中三种是在两项单独的研究中进行调查的。据报道，在一项研究中，红色分布宽度和平均血小板体积的特异性≥ 90%，尽管这些发现尚未得到其他研究的证实。大多数研究都存在很高的选择偏倚风险。 (4) 结论：纳入研究的适度研究结果和不确定的有效性表明，本系统评价中确定的生物标志物都没有潜力通过减少 CTPA 的过度使用来改进当前急性 PE 的诊断算法。
(1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency department with suspected acute PE. (2) Methods: Medline and Embase databases were searched from 1995 to the present. The study selection process, data extraction, and risk of bias assessment were conducted by two reviewers. Eligibility criteria accepted all blood biomarkers except D-dimer, and CTPA was used as the reference standard. Qualitative data synthesis was performed. (3) Results: Of the 8448 identified records, only 6 were included. Eight blood biomarkers were identified, of which, three were investigated in two separate studies. Red distribution width and mean platelet volume were reported to have a specificity of ≥ 90% in one study, although these findings were not confirmed by other studies. The majority of the studies contained a high risk of selection bias. (4) Conclusions: The modest findings and the uncertain validity of the included studies suggest that none of the biomarkers identified in this systematic review have the potential to improve the current diagnostic algorithm for acute PE by reducing the overuse of CTPA.
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DOI：
10.23750/abm.v92i5.9752
发表时间：
2021-11-03
期刊：
Acta bio-medica : Atenei Parmensis
影响因子：
--
作者：
Bonfanti L;Cervellin G;Calamai S;Lunian M;Aloe R;Lippi G
通讯作者：
Lippi G
影响因子：
5
作者：
Costantino, Mary M.;Randall, Geneva;Vegas, C. David
通讯作者：
Vegas, C. David
影响因子：
2.7
作者：
Farah, Raymond;Nseir, William;Khamisy-farah, Rola
通讯作者：
Khamisy-farah, Rola
影响因子：
9.3
作者：
Leeflang, Mariska M. G.;Moons, Karel G. M.;Zwinderman, Aielko H.
通讯作者：
Zwinderman, Aielko H.
影响因子：
2.9
作者：
Kalkan, Ali Kemal;Ozturk, Derya;Celik, Ahmet
通讯作者：
Celik, Ahmet