Structural changes and the storage of long-term memory in Aplysia
Structural changes and the storage of long-term memory in Aplysia
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DOI：
10.1139/cjpp-77-9-738
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发表时间：
1999-09-01
影响因子：
2.1
通讯作者：
Bailey, CH
中科院分区：
文献类型：
--
作者：
Bailey, CH
长时程记忆与感觉神经元和运动神经元之间新的突触连接的生长有关。这种结构变化的持续时间与记忆的行为保持平行。这种变化可以在解离细胞培养物中通过反复呈现调节性神经递质5-羟色胺（5-HT）来重建，并且与NCAM相关细胞粘附分子的活性依赖性下调相关，NCAM相关细胞粘附分子被认为有助于发育期间的细胞识别和轴突生长。因此，学习相关的突触生长的经验，在成人中使用的机制方面，最终可以理解的分子逻辑的背景下，形状突触电路在神经元发育的后期阶段。
Long-term memory for sensitization of the gill-withdrawal reflex inAplysia is associated with the growth of new synaptic connections between sensory and motor neurons. The duration of this structural change parallels the behavioral retention of the memory. Such changes can be reconstituted in dissociated cell culture by repeated presentations of the modulatory neurotransmitter serotonin (5HT) and are associated with an activity-dependent downregulation of NCAM-related cell adhesion molecules thought to contribute to cell recognition and axonal outgrowth during development. Thus, aspects of the mechanisms utilized for learning-related synaptic growth initiated by experience in the adult may eventually be understood in the context of the molecular logic that shapes synaptic circuitry during the later stages of neuronal development.