Grid-like hexadirectional modulation of human entorhinal theta oscillations
Grid-like hexadirectional modulation of human entorhinal theta oscillations
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DOI：
10.1073/pnas.1805007115
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发表时间：
2018-10-16
影响因子：
11.1
通讯作者：
Jacobs, Joshua
中科院分区：
文献类型：
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作者：
Maidenbaum, Shachar;Miller, Jonathan;Jacobs, Joshua
内嗅皮层包含一个网格细胞网络，这些细胞在大脑的空间系统中扮演着基本的角色，支持路径整合和空间记忆等任务。在啮齿动物中，网格细胞被认为依赖于网络theta振荡，但这种信号在所有物种中并不明显，这挑战了我们对网格网络的生理基础的理解。我们分析了神经外科患者在虚拟导航过程中的颅内记录，以确定人类内嗅网的振荡特征。根据导航过程中的虚拟航向，内脏theta振荡的功率显示出六倍的调制，这是网格表示的假想特征。此外，调制强度与空间记忆成绩相关。这些结果证明了theta振荡与人类内嗅觉网格网络之间的联系，并表明可以从群体电生理记录中识别网格状神经元表征的特征。
The entorhinal cortex contains a network of grid cells that play a fundamental part in the brain's spatial system, supporting tasks such as path integration and spatial memory. In rodents, grid cells are thought to rely on network theta oscillations, but such signals are not evident in all species, challenging our understanding of the physiological basis of the grid network. We analyzed intracranial recordings from neurosurgical patients during virtual navigation to identify oscillatory characteristics of the human entorhinal grid network. The power of entorhinal theta oscillations showed six-fold modulation according to the virtual heading during navigation, which is a hypothesized signature of grid representations. Furthermore, modulation strength correlated with spatial memory performance. These results demonstrate the connection between theta oscillations and the human entorhinal grid network and show that features of grid-like neuronal representations can be identified from population electrophysiological recordings.