Concise synthesis of artemisinin from a farnesyl diphosphate analogue
Concise synthesis of artemisinin from a farnesyl diphosphate analogue
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DOI：
10.1016/j.bmc.2017.03.068
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发表时间：
2018-04-01
影响因子：
3.5
通讯作者：
Allemann, Rudolf K.
中科院分区：
文献类型：
--
作者：
Tang, Xiaoping;Demiray, Melodi;Allemann, Rudolf K.
青蒿素是最有效的抗疟疾药物之一，许多通常漫长的合成路线已经开发出来。Amorphadiene合酶是青蒿素生物合成途径中的关键酶，能够将含氧法呢基二磷酸类似物直接转化为双氢青蒿醛，双氢青蒿醛仅需四个化学步骤即可转化为青蒿素，从而为抗疟疾药物提供了一条有效的合成路线。(C)2017作者由爱思唯尔有限公司发布
Artemisinin is one of the most potent anti-malaria drugs and many often-lengthy routes have been developed for its synthesis. Amorphadiene synthase, a key enzyme in the biosynthetic pathway of artemisinin, is able to convert an oxygenated farnesyl diphosphate analogue directly to dihydroartemisinic aldehyde, which can be converted to artemisinin in only four chemical steps, resulting in an efficient synthetic route to the anti-malaria drug. (C) 2017 The Authors. Published by Elsevier Ltd.