Engineering approaches for investigating tumor angiogenesis: exploiting the role of the extracellular matrix.
Engineering approaches for investigating tumor angiogenesis: exploiting the role of the extracellular matrix.
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DOI：
10.1158/0008-5472.can-12-2773
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发表时间：
2012-12-01
期刊：
影响因子：
11.2
通讯作者：
Gerecht S
中科院分区：
文献类型：
--
作者：
Hielscher AC;Gerecht S
癌症研究的一个主要范式转变是多学科方法的出现，以研究复杂的细胞行为，阐明调控机制和确定治疗靶点。最近，人们的努力集中在复杂的体外模型的工程设计上，这些模型更准确地概括了癌症的生长和进展。这些策略已被证明对于研究和靶向控制肿瘤血管生成的事件至关重要。在这篇综述中，我们将探讨如何利用新兴的工程方法来解开调节肿瘤血管生成的复杂机制。重点放在使用天然和合成生物材料的模型上，以产生模拟细胞外基质（ECM）的支架，ECM在血管生成中起着关键作用。虽然在这篇评论中提出的模型是革命性的，改进仍然是必要的，并提出了推进和完善工程方法建模肿瘤血管生成的概念。总的来说，不同科学领域之间的结合有望显著改善我们对癌症的理解和治疗。
A major paradigm shift in cancer research is the emergence of multidisciplinary approaches to investigate complex cell behaviors to elucidate the regulatory mechanisms and to identify therapeutic targets. Recently, efforts are focused on the engineering of complex in-vitro models, which more accurately recapitulate the growth and progression of cancer. These strategies have proven vital for investigating and targeting the events that control tumor angiogenesis. In this review, we explore how the emerging engineering approaches are being utilized to unlock the complex mechanisms regulating tumor angiogenesis. Emphasis is placed on models employing natural and synthetic biomaterials to generate scaffolds mimicking the extracellular matrix (ECM) which plays a critical role in angiogenesis. While the models presented in this review are revolutionary, improvements are still necessary and concepts for advancing and perfecting engineering approaches for modeling tumor angiogenesis are proposed. Overall, the marriage between disparate scientific fields is expected to yield significant improvements of our understanding and treatment of cancer.