FERROUS ION-EDTA-STIMULATED PHOSPHOLIPID PEROXIDATION - A REACTION CHANGING FROM ALKOXYL-RADICAL-DEPENDENT TO HYDROXYL-RADICAL-DEPENDENT INITIATION
FERROUS ION-EDTA-STIMULATED PHOSPHOLIPID PEROXIDATION - A REACTION CHANGING FROM ALKOXYL-RADICAL-DEPENDENT TO HYDROXYL-RADICAL-DEPENDENT INITIATION
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DOI：
10.1042/bj2240697
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发表时间：
1984-01-01
影响因子：
4.1
通讯作者：
GUTTERIDGE, JMC
中科院分区：
文献类型：
--
作者：
GUTTERIDGE, JMC
当Fe ~（2+）浓度大于EDTA浓度时，EDTA可增强亚铁盐对磷脂过氧化反应的促进作用。羟基自由基清除剂不抑制过氧化反应，直到在反应中的Fe 2+和EDTA的浓度是相等的。然后，脂质过氧化反应基本上由来自需要H2 O2的芬顿型反应的羟基自由基引发。超氧自由基似乎在引发物种的形成中起一定作用。
The stimulatory effect of ferrous salts on the peroxidation of phospholipids can be enhanced by EDTA when the concentration of Fe2+ in the reaction is greater than that of EDTA. Hydroxy radical scavengers do not inhibit peroxidation until the concentrations of Fe2+ and EDTA in the reaction are equal. Lipid peroxidation is then substantially initiated by hydroxyl radicals derived from a Fenton-type reaction requiring H2O2. Superoxide radicals appear to play some role in the formation of initiating species.