INCREASED COMPOUND 48/80 INDUCED LOCAL HISTAMINE-RELEASE FROM NONLESIONAL SKIN OF PATIENTS WITH CHRONIC URTICARIA
INCREASED COMPOUND 48/80 INDUCED LOCAL HISTAMINE-RELEASE FROM NONLESIONAL SKIN OF PATIENTS WITH CHRONIC URTICARIA
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DOI：
10.1016/0091-6749(86)90260-5
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发表时间：
1986-12-01
影响因子：
14.2
通讯作者：
HEBERT, J
中科院分区：
文献类型：
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作者：
BEDARD, PM;BRUNET, C;HEBERT, J
用皮肤室技术测定了特发性慢性荨麻疹(CU)患者和正常志愿者正常皮肤部位皮肤肥大细胞释放的组胺。在4小时的观察中，两组患者都自发并持续释放少量组胺，但CU患者的组胺释放量是对照组的两倍。此外，在用化合物48/80激发的部位，组胺水平显著高于未刺激部位。CU患者与正常志愿者的不同之处在于，48/80化合物诱导的组胺释放在攻击后1小时和2小时显著增加。两组大鼠皮肤肥大细胞数量和组胺含量无明显差异。这些模糊可能表明肥大细胞水平上的功能缺陷，而不是它们数量上的差异。
Histamine released from skin mast cells in normal skin sites of patients with idiopathic chronic urticaria (CU) and normal volunteers was assessed with the skin chamber technique. Small amounts of histamine were spontaneously and continuously released during the 4-hour observation in both groups but were twofold greater in patients with CU. In addition, histamine levels were significantly more elevated in sites challenged with compound 48/80 than in unstimulated sites. Patients with CU differed from normal volunteers in that histamine release induced by 48/80 compound was significantly greater at 1 and 2 hours after challenge. The number of mast cells and the histamine content of the skin did not differ in the two groups. These obsrvations could suggest a functional defect at the mast cell level rather than a difference in their numbers.