Cytotoxic diterpenoids from Rabdosia lophanthoides var. gerardianus
Cytotoxic diterpenoids from Rabdosia lophanthoides var. gerardianus
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Rabdosia lophanthoides var. 的细胞毒性二萜类化合物。
DOI：
10.1016/j.fitote.2015.11.015
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发表时间：
2016-03-01
期刊：
影响因子：
3.4
通讯作者：
Zhu, Chen-Chen
中科院分区：
文献类型：
--
作者：
Lin, Chao-Zhan;Zhao, Wei;Zhu, Chen-Chen
从香茶菜（Rabdosia lophanthoides var.）的地上部分分离得到两个新的松香烷型二萜化合物Gerardianin B（1）和Gerardianin C（2），一个新的木脂素苷Gerardianin D（3）和一个新的羽扇烷型三萜化合物Gerardianol A（4），以及七个已知的松香烷型二萜化合物。gerardianus。通过1D和2D NMR数据确定了它们的结构。在人癌细胞系上评价9种二萜类化合物的细胞毒活性。化合物6-11对HepG 2细胞和HCF-8细胞均表现出明显的细胞毒活性，IC 50分别为4.68 - 9.43 M和9.12 - 13.53 M。(C)2015年由Elsevier B. V.出版
Two new abietane diterpenoids, Gerardianin B (1) and Gerardianin C (2), one new lignan glycoside, Gerardianin D (3) and one new lupane-type triterpenoid, Gerardianol A (4), together with seven known abietane diterpenoids were isolated from the aerial parts of Rabdosia lophanthoides var. gerardianus. Their structures were determined by 1D and 2D NMR spectroscopic data. The cytotoxic activities of the nine diterpenoids were evaluated on human cancer cell lines. Compounds 6-11 exhibited significant cytotoxic activities against HepG2 cell lines with IC50 from 4.68 to 9.43 M and HCF-8 cell lines with IC50 from 9.12 to 13.53 M. (C) 2015 Published by Elsevier B.V.