T1 contrast in the myocardium and blood pool: a quantitative assessment of gadopentetate dimeglumine and gadofosveset trisodium at 1.5 and 3 T.
T1 contrast in the myocardium and blood pool: a quantitative assessment of gadopentetate dimeglumine and gadofosveset trisodium at 1.5 and 3 T.
复制标题
心肌和血池中的 T1 对比：在 1.5 和 3 T 下对钆喷酸二葡胺和钆磷维特三钠进行定量评估。
DOI：
10.1097/rli.0000000000000024
复制
发表时间：
2014
影响因子：
6.7
通讯作者：
Carr,JamesC
中科院分区：
文献类型：
--
作者：
Lin,Kai;Lloyd-Jones,DonaldM;Spottiswoode,Bruce;Bi,Xiaoming;Liu,Ying;Lu,Biao;Xue,Huadan;Wang,Yining;Li,Debiao;Carr,JamesC
ObjectivesThe本研究的目的是评估心血管组织，造影剂，和磁场strengths.Materials和MethodsThis健康保险便携性和责任法案兼容的研究之间的T1对比度（T1 C）的演变被批准的机构审查委员会，并从所有参与者获得书面知情同意书。招募8名健康志愿者，以相同的成像参数进行4次连续磁共振（MR）扫描。扫描1和2使用3-T MR扫描仪进行，扫描3和4使用1.5-T MR扫描仪进行。扫描1和3注射钆磷维司三钠（0.03 mmol/kg），扫描2和4使用钆喷酸葡胺（Gd-DTPA）（0.1 mmol/kg）。在造影剂给药前，每5分钟重复一次，直到给药后45分钟，获得改良Look-T1反转恢复T1图和心室中短轴视图。T1对比组织（T1心肌-T1血液），T1 c剂（T1 Gd-DTPA-T1 Gadofosveset），和T1 c场（T1 3 T-T1 1.5 T）进行计算和比较，使用t检验.ResultsThe T1 c组织的3-T扫描仪大于1.5-T扫描仪的两种造影剂。在心肌和血池中，1.5-T扫描仪的T1 c剂大于3-T扫描仪。Gadofosveset三钠表现出更大的T1 c字段和T1 c组织比Gd-DTPA。Gd-DTPA诱导的T1 C组织比钆磷维司三钠在1.5和3 T.ConclusionsOur study demonstrates independent effects of timing，contrast agent type，and magnetic field strength on postcontrast T1 C under general physical conditions. T1 c的行为可用于定制用于各种临床目的的定量MR成像协议。
ObjectivesThe objective of this study was to assess the evolution of T1 contrast (T1c) between cardiovascular tissues, contrast agents, and magnetic field strengths.Materials and MethodsThis Health Insurance Portability and Accountability Act-compliant study was approved by the institutional review board, and written informed consent was obtained from all participants. Eight healthy volunteers were recruited to undergo 4 consecutive magnetic resonance (MR) scans with the same imaging parameters. Scans 1 and 2 were performed using a 3-T MR scanner, and scans 3 and 4 were performed using a 1.5-T MR scanner. Gadofosveset trisodium (0.03 mmol/kg) was injected for scans 1 and 3, and gadopentetate dimeglumine (Gd-DTPA)(0.1 mmol/kg) was used for scans 2 and 4. Modified Look-Locker inversion recovery T1 maps with a midventricular short-axis view were acquired before contrast and repeated every 5 minutes until 45 minutes after contrast agent administration. T1 contrast tissue (T1 myocardium− T1 blood), T1c agent (T1 Gd-DTPA-T1 Gadofosveset), and T1c field (T1 3T-T1 1.5 T) were calculated and compared using t tests.ResultsThe T1c tissue of the 3-T scanner was larger than that of the 1.5-T scanner for both contrast agents. In both the myocardium and the blood pool, the T1c agent of the 1.5-T scanner was larger than that of the 3-T scanner. Gadofosveset trisodium exhibited a larger T1c field and T1c tissue than did Gd-DTPA. The T1c tissue induced by Gd-DTPA diminished faster than that induced by gadofosveset trisodium at both 1.5 and 3 T.ConclusionsOur study demonstrates the independent effects of timing, contrast agent type, and magnetic field strength on postcontrast T1c under general physiological conditions. The behaviors of T1c can be used to tailor quantitative MR imaging protocols for various clinical purposes.