SWELLING PRESSURE OF THE LUMBAR INTERVERTEBRAL DISKS - INFLUENCE OF AGE, SPINAL LEVEL, COMPOSITION, AND DEGENERATION
SWELLING PRESSURE OF THE LUMBAR INTERVERTEBRAL DISKS - INFLUENCE OF AGE, SPINAL LEVEL, COMPOSITION, AND DEGENERATION
复制标题
DOI：
10.1097/00007632-198802000-00009
复制
发表时间：
1988-02-01
期刊：
影响因子：
3
通讯作者：
MCMULLIN, JF
中科院分区：
文献类型：
--
作者：
URBAN, JPG;MCMULLIN, JF
椎间盘的流体含量在确定其机械响应以及其运输和生物学特性方面是重要的。液体含量取决于组织的蛋白多糖含量以及外部负荷与椎间盘膨胀压力的关系。本文测定了32个人腰椎间盘髓核水化过程中蛋白多糖含量和外负荷的影响。用平衡透析法测定相同试样的膨胀压。观察了年龄（14-91岁）和脊柱节段的影响。椎间盘的蛋白多糖含量随着年龄的增长而下降，对于所有测试的脊柱，L5-S1椎间盘的蛋白多糖含量最低;胶原蛋白含量没有系统性变化。椎间盘的水合作用也随着年龄的增长而下降;在每个完整的腰椎测试中，L1-L2和L5-S1椎间盘在死后检查时水合作用最低。随着施加到圆盘上的应力增加，水合作用降低。虽然0.10-0.23 MPa的应力使椎间盘切片保持死后水合，但在约0.6-0.8 MPa的应力下，大多数椎间盘损失了其初始流体的40-60%。水化和膨胀压力的变化之间的关系被发现取决于椎间盘的组成，而不是年龄或变性程度;平衡水化和膨胀压力之间的关系可以令人满意地预测一个已知的胶原蛋白和蛋白多糖含量的椎间盘。
The fluid content of the intervertebral disc is important in determining its mechanical response and also its transport and biologic properties. Fluid content depends on the proteoglycan content of the tissue and on the relationship of the external load to the disc''s swelling pressure. The influence of proteoglycan content and external load on the hydration of nuclei from 32 human lumbar discs was measured. Swelling pressure of the same specimens was measured by equilibrium dialysis. The influence of age (14-91 years) and spinal level was noted. Proteoglycan content of the discs fell with age, and for all spines tested, proteoglycan content was lowest in the L5-S1 disc; no systematic change in collagen content was found. The hydration of the discs, as received, also fell with increase in age; in each complete lumbar spine tested, the L1-L2 and the L5-S1 discs had the lowest hydration at postmortem examination. As the stress applied to the discs were increased, hydration decreased. Although a stress of 0.10-0.23 MPa maintained the discs slices at their postmortem hydration, under a stress of about 0.6-0.8 MPa, most discs lost 40-60% of their initial fluid. The relationship between change in hydration and swelling pressure was found to depend on the composition of the disc rather than on age or degree of degeneration; the relationship between equilibrium hydration and swelling pressure could be predicted satisfactorily for a disc of known collagen and proteoglycan content.