A Data Mining-Based Study on Medication Rules of Chinese Herbs to Treat Heart Failure with Preserved Ejection Fraction
A Data Mining-Based Study on Medication Rules of Chinese Herbs to Treat Heart Failure with Preserved Ejection Fraction
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DOI：
10.1007/s11655-022-2892-5
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发表时间：
2022-07-12
影响因子：
2.9
通讯作者：
Zhu Ming-jun
中科院分区：
文献类型：
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作者：
Guo Hong-xin;Wang Jian-ru;Zhu Ming-jun
目的基于数据挖掘技术总结治疗射血分数保留性心力衰竭（HFPEF）的中药用药规律，为临床用药提供参考。方法计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、科克伦图书馆等数据库，检索时间为2021年10月至2021年10月，检索中药治疗HFPEF的相关文献。使用Microsoft Excel 2019建立数据库，然后在R-Studio（版本4.0.3）中分别使用apriori算法和history函数进行关联规则分析和层次聚类分析。结果共纳入182篇合格论文，涉及方剂92个，中药130味，单味药872味，平均每方含药9.5味。最常见的6种药物是黄芪、丹参、茯苓、甘草、桂枝和人参。用药5次以上的有35味，涉及11个功效类别。排名前三位的分别是补虚药、活血化瘀药和利湿利水药。最常用的药，以温甘为主。主要归经为肺经、心经、脾经。关联规则分析得到黄芪与丹参、茯苓、桂枝与白术等26条关联规则。系统聚类分析结果表明，中药可分为4类，其作用以益气温阳、活血利尿为主。结论HFPEF为本虚端实证，其核心病机为“虚”、“瘀”、“水”，其中“虚”为最主要病机，与心、肺、脾密切相关。本病的治疗以益气温阳、活血利水为主。黄芪与丹参是中药的基本配伍。
Objective To summarize the medication rules of Chinese herbs to treat heart failure with preserved ejection fraction (HFPEF) based on data mining and to provide references for clinical utilization. Methods The China National Knowledge Infrastructure (CNKI), Wanfang database (Wanfang), VIP database (VIP), Chinese Biomedical Literature (CBM), PubMed, Embase, and Cochrane Library databases were searched from inception to October 2021 to identify relevant literature on treating HFPEF with Chinese herbs. Microsoft Excel 2019 was used to set up a database, and then, association rule analysis and hierarchical cluster analysis were performed by using apriori algorithm and hclust function respectively in R-Studio (Version 4.0.3). Results A total of 182 qualified papers were included, involving a total of 92 prescriptions, 130 Chinese herbs, and 872 individual herbs prescribed, with an average of 9.5 herbs per prescription. The six most frequently prescribed herbs were Astragali Radix (Huangqi), Salviae Miltiorrhizae Radix Et Rhizoma (Danshen), Poria (Fuling), Glycyrrhizae Radix Et Rhizoma (Gancao), Cinnamomi Ramulus (Guizhi), and Ginseng Radix Et Rhizoma (Renshen). There were 35 herbs used more than 5 times, involving 11 efficacy categories. The top three categories were deficiency-tonifying herbs, blood-activating and stasis-removing herbs, and dampness-draining diuretic herbs. The most commonly used herbs were mainly warm and sweet. The primary meridian tropisms were Lung Meridian, Heart Meridian and Spleen Meridian. Association rule analysis yielded 26 association rules, such as Astragali Radix (Huangqi) & Salviae Miltiorrhizae Radix Et Rhizoma (Danshen), Poria (Fuling), Cinnamomi Ramulus (Guizhi) & Atractylodis Macrocephalae Rhizoma (Baizhu). Hierarchical cluster analysis yielded four herb classes, and their functions were mainly qi-replenishing and yang-warming, blood-activating and diuresis-inducing. Conclusions HFPEF is the syndrome of root vacuity and tip repletion, and its core pathogenesis is "deficiency", "stasis", and "water", with "deficiency" being the most principal, which is closely related to Xin (heart), Fei (Lung), and Pi (Spleen). The treatment of this disease occurs by improving qi, warming yang, activating blood and inducing diuresis. Astragali Radix (Huangqi) with Salviae Miltiorrhizae Radix Et Rhizoma (Danshen) is the basic combination of herbs applied.