The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients.
The Metabonomic Studies of Tongue Coating in H. pylori Positive Chronic Gastritis Patients.
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H. pylori阳性慢性胃炎患者舌苔代谢组学研究
DOI：
10.1155/2015/804085
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Li Q
中科院分区：
文献类型：
--
作者：
Liu X;Sun ZM;Liu YN;Ji Q;Sui H;Zhou LH;Li FF;Li Q
在中国传统医学中，舌诊作为一种重要的诊断方法已有3000多年的历史。舌苔可以作为判断慢性胃炎病情进展的一个非常敏感的指标。因此，科学、定性、定量地研究舌苔的病理生理基础成为舌苔客观化研究的主要方向。在本研究中，我们利用GC/MS技术来确定代谢物的潜在变化，并确定了H. pylori感染的慢性胃炎患者。通过GC/MS鉴定了4个区别性代谢产物。pylori感染（G + H）和无H。幽门螺杆菌感染（G-H）患者TC的主要代谢产物为乙烯、头孢啶、γ-氨基丁酸和5-焦谷氨酸，提示TC的形成可能与氨基酸代谢的改变有关，氨基酸代谢产物是G + H患者TC物质组成的一部分。
In Traditional Chinese Medicine (TCM), tongue diagnosis (TD) has been an important diagnostic method for the last 3000 years. Tongue coating can be used as a very sensitive marker to determine the progress of chronic gastritis. Therefore, the scientific, qualitative, and quantitative study for the pathophysiologic basis of tongue coating (TC) emerged as a major direction for the objective research of TD. In our current report, we used GC/MS technology to determine the potential changes of metabolites and identify special metabolic biomarkers in the TC of H. pylori infected chronic gastritis patients. Four discriminative metabolites were identified by GC/MS between the TC of H. pylori infection (G + H) and without H. pylori infection (G − H) patients: ethylene, cephaloridine, γ-aminobutyric acid, and 5-pyroglutamic acid, indicating that changes in amino acid metabolism are possibly involved in the formation of TC, and the amino acid metabolites are part of the material components of TC in G + H patients.