Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients
Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients
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DOI：
10.1016/j.diabres.2010.11.030
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发表时间：
2011-07-01
影响因子：
5.1
通讯作者：
Bhattacharyya, Maitree
中科院分区：
文献类型：
--
作者：
Chakraborty, Arpita;Chowdhury, Subhankar;Bhattacharyya, Maitree
目的：在过去的三十年里，先进的研究已经从根本上改变了糖尿病的诊断和治疗;目前有许多种类的口服降糖药可用于更好地控制血糖。本研究旨在评估二甲双胍对糖尿病患者不同应激和炎症参数的影响。方法：208例2型糖尿病患者随机分为二甲双胍组和安慰剂组。活性氧生成，高级氧化蛋白产物与安慰剂相比，二甲双胍治疗降低了戊糖苷（179.65 +/- 13.6，120.65 +/- 10.5 mmol/l）和戊糖苷（107 +/- 10.4，78 +/- 7.6 pmol/ml）。另一方面，二甲双胍给药提高了总巯基和一氧化氮水平（p < 0.05）。但血浆中的营养素水平（Mg+2，Ca+2）不受处理的影响。二甲双胍治疗后C反应蛋白显著恢复（p < 0.05）。二甲双胍给药还改善了红细胞膜Na+K+ ATP酶活性（0.28 +/- 0.08，0.41 +/- 0.07 μ mol Pi/mg/h）。结论：本研究探讨二甲双胍治疗恢复2型糖尿病患者的抗氧化状态、酶活性和炎症参数。二甲双胍治疗可改善2型糖尿病患者的氧化和亚硝化应激状态。本研究揭示了二甲双胍作为口服降糖药的心脏保护作用。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Aim: Advanced research has radically changed both diagnosis and treatment of diabetes during last three decades; a number of classes of oral antidiabetic agents are currently available for better glycemic control. Present study aims to evaluate the effect of metformin on different stress and inflammatory parameters in diabetic subjects.Methods: 208 type 2 diabetes patients were randomly assigned for metformin and placebo.Results: Reactive oxygen species generation, advanced oxidation protein products (179.65 +/- 13.6, 120.65 +/- 10.5 mmol/l) and pentosidine (107 +/- 10.4, 78 +/- 7.6 pmol/ml) were found to be reduced by metformin treatment compared to placebo. On the other hand metformin administration enhanced total thiol and nitric oxide level (p < 0.05). But nutrient level (Mg+2, Ca+2) in plasma was not altered by the treatment. Significant restoration of C reactive protein (p < 0.05) was noticed after metformin therapy. Metformin administration also improved Na+K+ ATPase activity (0.28 +/- 0.08, 0.41 +/- 0.07 mu mol Pi/mg/h) in erythrocyte membrane.Conclusions: This study explores that metformin treatment restores the antioxidant status, enzymatic activity and inflammatory parameters in type 2 diabetic patients. Metformin therapy improves the status of oxidative and nitrosative stress altered in type 2 diabetes. This study unfolds the cardio protective role of metformin as an oral hypoglycemic agent. (C) 2010 Elsevier Ireland Ltd. All rights reserved.