Breast-feeding protects against celiac disease
Breast-feeding protects against celiac disease
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DOI：
10.1093/ajcn/75.5.914
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发表时间：
2002-05-01
影响因子：
7.1
通讯作者：
Persson, LÅ
中科院分区：
文献类型：
--
作者：
Ivarsson, A;Hernell, O;Persson, LÅ
背景资料：乳糜泻，或永久性麸质敏感性肠病，是一种免疫性疾病，严格依赖于暴露于小麦面筋或相关蛋白质在黑麦和大麦.Objective：本研究的目的是探讨是否母乳喂养和模式引入膳食麸质影响乳糜泻的风险在儿童期。设计：一项以人群为基础的瑞典儿童事件病例参照研究，627例乳糜泻患者和1254例参照。78%的匹配集被纳入最终分析。调查问卷被用来评估婴儿的食物引入模式。根据目前流行病学和免疫学对乳糜泻的认识，建立模型，研究饮食模式对疾病风险的潜在影响，并在多变量分析中通过条件Logistic回归进行评估。
Background: Celiac disease, or permanent gluten-sensitive enteropathy, is an immunologic disease strictly dependent on exposure to wheat gluten or related proteins in rye and barley.Objective: The aim of this study was to explore whether breast-feeding and the mode of introducing dietary gluten influence the risk of celiac disease in childhood.Design: A population-based incident case-referent study of Swedish children, 627 cases with celiac disease and 1254 referents. was conducted 78% of the matched sets were included in the final analyses. A questionnaire was used to assess patterns of food introduction to infants. Models were built, based on current epidemiologic and immunologic knowledge of celiac disease, to study the potential influence of dietary patterns on disease risk and were evaluated by conditional logistic regression in multivariate analyses.Results: The risk of celiac disease was reduced in children aged