Arterial pulsations drive oscillatory flow of CSF but not directional pumping
Arterial pulsations drive oscillatory flow of CSF but not directional pumping
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DOI：
10.1038/s41598-020-66887-w
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发表时间：
2020-06-22
影响因子：
4.6
通讯作者：
Costanzo, Francesco
中科院分区：
文献类型：
--
作者：
Kedarasetti, Ravi Teja;Drew, Patrick J.;Costanzo, Francesco
大脑缺乏传统的淋巴系统来清除代谢物。存在“胶质淋巴系统”，其中代谢物通过间质液（ISF）和脑脊液（CSF）之间沿着脑血管周围的血管旁间隙（PVS）的对流交换从脑的细胞外间隙移除，这一直是有争议的。虽然最近的工作已经显示了明确的证据，在麻醉小鼠的PVS中的CSF的定向流动，所观察到的流体流动的驱动力仍然难以捉摸。心跳驱动的动脉蠕动脉动已被提出作为定向CSF流动的可能驱动因素。在这项研究中，我们使用严格的流体动力学模拟提供了一个物理解释蠕动泵送的流体。我们的模拟结果与实验结果相匹配，并表明动脉搏动只驱动PVS中CSF的振荡运动。观察到的定向CSF流动可以通过自然发生的和/或实验者产生的压差来解释。
The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral blood vessels has been controversial. While recent work has shown clear evidence of directional flow of CSF in the PVS in anesthetized mice, the driving force for the observed fluid flow remains elusive. The heartbeat-driven peristaltic pulsation of arteries has been proposed as a probable driver of directed CSF flow. In this study, we use rigorous fluid dynamic simulations to provide a physical interpretation for peristaltic pumping of fluids. Our simulations match the experimental results and show that arterial pulsations only drive oscillatory motion of CSF in the PVS. The observed directional CSF flow can be explained by naturally occurring and/or experimenter-generated pressure differences.