Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities.
Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities.
复制标题
DOI：
10.3389/fmicb.2011.00258
复制
发表时间：
2011
影响因子：
5.2
通讯作者：
Iwatani Y
中科院分区：
文献类型：
--
作者：
Kitamura S;Ode H;Iwatani Y
人APOBEC 3（A3）蛋白是细胞胞苷脱氨酶，其通过超突变病毒cDNA和/或抑制逆转录而有效地限制逆转录病毒的复制。该家族有七个成员，包括A3 A、B、C、DE、F、G和H，所有成员都编码在人类22号染色体上的串联阵列中。A3 F和A3 G是HIV-1最有效的抑制剂，但仅在缺乏病毒编码蛋白Vif的情况下。HIV-1利用Vif消除生产细胞中的A3功能。更具体地说，Vif作为底物受体，通过形成基于Cullin 5（Cul 5）的E3泛素连接酶复合物促进A3蛋白的泛素化，该复合物靶向A3蛋白进行快速蛋白酶体降解。A3降解的特异性取决于Vif与靶标结合的能力。几条证据表明，A3蛋白的三个不同区域参与了与Vif的相互作用。在这里，我们回顾了A3家族成员的生物学功能，特别关注A3 G，并根据现有的结构信息进行分析。
Human APOBEC3 (A3) proteins are cellular cytidine deaminases that potently restrict the replication of retroviruses by hypermutating viral cDNA and/or inhibiting reverse transcription. There are seven members of this family including A3A, B, C, DE, F, G, and H, all encoded in a tandem array on human chromosome 22. A3F and A3G are the most potent inhibitors of HIV-1, but only in the absence of the virus-encoded protein, Vif. HIV-1 utilizes Vif to abrogate A3 functions in the producer cells. More specifically, Vif, serving as a substrate receptor, facilitates ubiquitination of A3 proteins by forming a Cullin5 (Cul5)-based E3 ubiquitin ligase complex, which targets A3 proteins for rapid proteasomal degradation. The specificity of A3 degradation is determined by the ability of Vif to bind to the target. Several lines of evidence have suggested that three distinct regions of A3 proteins are involved in the interaction with Vif. Here, we review the biological functions of A3 family members with special focus on A3G and base our analysis on the available structural information.
登录
查看更多内容
影响因子：
4.8
作者：
Dang, Ying;Siew, Lai Mun;Zheng, Yong-Hui
通讯作者：
Zheng, Yong-Hui
影响因子：
64.8
作者：
Sheehy, AM;Gaddis, NC;Malim, MH
通讯作者：
Malim, MH
影响因子：
64.8
作者：
Holden, Lauren G.;Prochnow, Courtney;Chang, Y. Paul;Bransteitter, Ronda;Chelico, Linda;Sen, Udayaditya;Stevens, Raymond C.;Goodman, Myron F.;Chen, Xiaojiang S.
通讯作者：
Chen, Xiaojiang S.
影响因子：
4.8
作者：
Albin, John S.;LaRue, Rebecca S.;Harris, Reuben S.
通讯作者：
Harris, Reuben S.
影响因子：
5.6
作者：
He, Zhiwen;Zhang, Wenyan;Yu, Xiao-Fang
通讯作者：
Yu, Xiao-Fang