Peptide receptors and immune-related proteins expressed in the digestive system of a urochordate, Ciona intestinalis.
Peptide receptors and immune-related proteins expressed in the digestive system of a urochordate, Ciona intestinalis.
复制标题
尾索动物消化系统中表达的肽受体和免疫相关蛋白。
DOI：
10.1007/s00441-019-03024-8
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kawada T
中科院分区：
文献类型：
--
作者：
Satake H;Matsubara S;Shiraishi A;Yamamoto T;Osugi T;Sakai T;Kawada T
消化系统负责营养摄入和防御病原微生物。因此，识别消化功能和免疫系统的调节因子是验证生物体的生命周期，稳态，生存策略和进化方面的关键步骤。在过去的十年中，关于海鞘中神经肽及其受体、可变区几丁质结合蛋白（VCBPs）和Toll样受体（TLR）的研究报道越来越多。基于质谱的肽组和基因组数据库搜索不仅检测到海鞘同源物或脊椎动物肽及其受体的原型，包括胆囊收缩素、促性腺激素释放激素、速激肽、降钙素和加压素，而且还检测到海鞘特异性神经肽，包括Ci-LF和Ci-YFV。还揭示了GnRH能信号传导的物种特异性调节，包括通过多种GnRH受体之间的异二聚化的独特信号传导控制。这些发现阐明了海鞘在研究脊索动物肽能系统的进化和多样性方面的重要意义。在C.已经显示，在先天免疫系统中，抗微生物抗体、VCBPs和TLR在识别外源性微生物中起主要作用。这些结果表明，先天免疫相关分子的共同功能和物种特异性之间的C。昆虫和脊椎动物。本文综述了近年来在C中主要神经肽及其受体、VCBPs和TLR的分子和功能特征以及进化方面的研究进展。好吧
The digestive system is responsible for nutrient intake and defense against pathogenic microbes. Thus, identification of regulatory factors for digestive functions and immune systems is a key step to the verification of the life cycle, homeostasis, survival strategy and evolutionary aspects of an organism. Over the past decade, there have been increasing reports on neuropeptides, their receptors, variable region-containing chitin-binding proteins (VCBPs) and Toll-like receptors (TLRs) in the ascidian,Ciona intestinalis. Mass spectrometry-based peptidomes and genome database-searching detected not onlyCionaorthologs or prototypes of vertebrate peptides and their receptors, including cholecystokinin, gonadotropin-releasing hormones, tachykinin, calcitonin and vasopressin but alsoCiona-specific neuropeptides including Ci-LFs and Ci-YFVs. The species-specific regulation of GnRHergic signaling including unique signaling control via heterodimerization among multiple GnRH receptors has also been revealed. These findings shed light on the remarkable significance of ascidians in investigations of the evolution and diversification of the peptidergic systems in chordates. In the defensive systems ofC. intestinalis, VCBPs and TLRs have been shown to play major roles in the recognition of exogenous microbes in the innate immune system. These findings indicate both common and species-specific functions of the innate immunity-related molecules betweenC. intestinalisand vertebrates. In this review article, we present recent advances in molecular and functional features and evolutionary aspects of major neuropeptides, their receptors, VCBPs and TLRs inC. intestinalis.