MECHANISMS OF EPITHELIAL INVAGINATION
MECHANISMS OF EPITHELIAL INVAGINATION
复制标题
DOI：
10.1086/414426
复制
发表时间：
1985-01-01
影响因子：
6.5
通讯作者：
ETTENSOHN, CA
中科院分区：
文献类型：
--
作者：
ETTENSOHN, CA
这篇综述关注的是在形态发生过程中导致上皮片内陷的机械力。目前人们对这个问题的兴趣日益浓厚，并且已经制定了各种模型来解释上皮折叠的机械方面，每种模型都有不同的侧重点。对与该问题相关的实验证据进行批判性评估得出以下结论。 (1) 最流行的内陷模型是一种基于微丝介导的细胞形状变化的模型，鉴于通常支持其的实验证据的局限性，应该重新审查。最近的透化上皮实验为证实该模型的有效性提供了一种有前途的方法。 (2) 目前基于上皮细胞粘附特性差异的假设与现有数据一致，但目前似乎无法直接测试。 (3)有证据表明，在某些上皮间质器官的分支形态发生过程中，细胞生长和分裂参与了内陷，但已表明，在其他情况下，这些过程不参与。 （4）最近的研究表明，一些上皮内陷伴随着细胞的运动，包括重排（最近邻居的交换）和内卷（周围细胞流入内陷区域）的形式。 (5)从现有数据中可以得出的一般结论是，上皮折叠的几种不同机制在形态发生过程中起作用。
This review is concerned with the mechanical forces that cause epithelial sheets to invaginate during morphogenesis. Interest in this problem is currently increasing and a variety of models, each with a different emphasis, have been formulated to explain mechanical aspects of epithelial folding. A critical evaluation of the experimental evidence bearing on this problem leads to the following conclusions. (1) The most popular model of invagination, one based on microfilament-mediated cell shape change, should be re-examined, given the limitations of the experimental evidence usually offered in its support. Recent experiments with permeabilized epithelia offer a promising approach for confirming the validity of this model. (2) Current hypotheses based on disparities in the adhesive properties of epithelial cells are consistent with available data, but appear to be impossible to test directly at this time. (3) There is evidence that suggests that cell growth and division are involved in invagination during the branching morphogenesis of some epithelio-mesenchymal organs, but it has been shown that these processes are not involved in other cases. (4) Recent studies demonstrate that some epithelial invaginations are accompanied by movements of cells, both in the form of rearrangement (exchange of nearest neighbors) and involution (flow of surrounding cells into the invaginating region). (5) A general conclusion that may be drawn from the data now available is that several different mechanisms of epithelial folding operate during morphogenesis.