The origins of cerebral palsy
The origins of cerebral palsy
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DOI：
10.1097/01.wco.0000218227.35560.0d
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发表时间：
2006-04-01
影响因子：
4.8
通讯作者：
Badawi, N
中科院分区：
文献类型：
--
作者：
Keogh, JM;Badawi, N
脑瘫是儿童时期最常见和最明显的运动障碍。它的病因仍然是一个热门的争论话题，有人认为它是对一种可避免的并发症的医疗管理不善的反映，有人认为它的起源是胎儿大脑发育的影响，沿着一条因果通路受到损害。这篇综述概述了2004/2005年的研究出版物的主题。最近的发现这篇综述着眼于最近的发现有关流行病学，感染和炎症，早产，多胎妊娠，血栓形成，遗传学，胎盘，脑性瘫痪的神经影像学和抢救治疗。今年的总结论文有助于澄清风险群体，并确定一些领域（例如，血栓形成倾向的管理和诱导体温过低的可能性），具有快速引入临床实践的潜力。然而，在这种神秘和多因素的情况下，进展仍然缓慢。新的工具，如磁共振成像提供了有价值的见解，导致脑瘫的病变，但损伤的途径仍然不清楚。脑瘫研究的未来在于了解脑瘫道路上多种因素的复杂相互作用，或者寻找最终的共同途径，如炎症，这可能是适合操作的。
Purpose of review Cerebral palsy is the most common and visible motor disability of childhood. Its aetiology remains a topic of hot debate between those who see it as a reflection of medical mismanagement of an avoidable complication and those who see its origins in the development of the fetal brain affected at many points along a causal pathway to damage. This review outlines the themes of research publications over the year 2004/2005.Recent findings The review looks at recent findings relating to epidemiology, infection and inflammation, prematurity, multiple pregnancy, thrombophilias, genetics, placenta, neuroimaging and rescue therapies in cerebral palsy.Summary Papers this year have helped clarify risk groups and identify some areas (e.g. the management of thrombophilias and the potential of induced hypothermia) with the potential to be rapidly introduced into clinical practice. In this enigmatic and multifactorial condition, however, progress remains slow. New tools such as magnetic resonance imaging are providing valuable insights into the lesions that result in cerebral palsy but the pathways to injury remain unclear. The future of cerebral palsy research lies in understanding the complex interactions of multiple factors on the road to cerebral palsy or in looking for final common pathways such as inflammation which may be amenable to manipulation.