Covid-19 deaths in Africa: prospective systematic postmortem surveillance study
Covid-19 deaths in Africa: prospective systematic postmortem surveillance study
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DOI：
10.1136/bmj.n334
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发表时间：
2021-02-17
影响因子：
105.7
通讯作者：
Thea, Donald
中科院分区：
文献类型：
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作者：
Mwananyanda, Lawrence;Gill, Christopher J.;Thea, Donald
目的：为了直接测量2019年新冠肺炎在非洲城市人群中的致命影响。设计前瞻性系统的死后监测研究。设定赞比亚最大的三级护理转诊医院。部分病例：在赞比亚卢萨卡大学教学医院的太平间，所有年龄的死者在死亡48小时内登记。主要结果测量尸检鼻咽拭子通过逆转录定量聚合酶链式反应检测严重急性呼吸综合征冠状病毒2(SARS-CoV-2)。死亡按Covis-19状态、地点、年龄、性别和潜在危险因素分层。结果：372名参与者在2020年6月至9月间登记；有364人(97.8%)获得了聚合酶链式反应结果。根据建议的周期阈值，58/364例(15.9%)检出SARS-CoV-2
OBJECTIVETo directly measure the fatal impact of coronavirus disease 2019 (covid-19) in an urban African population.DESIGNProspective systematic postmortem surveillance study.SETTINGZambia's largest tertiary care referral hospital.PARTICIPANTSDeceased people of all ages at the University Teaching Hospital morgue in Lusaka, Zambia, enrolled within 48 hours of death.MAIN OUTCOME MEASUREPostmortem nasopharyngeal swabs were tested via reverse transcriptase quantitative polymerase chain reaction (PCR) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Deaths were stratified by covis-19 status, location, age, sex, and underlying risk factors.RESULTS372 participants were enrolled between June and September 2020; PCR results were available for 364 (97.8%). SARS-CoV-2 was detected in 58/364 (15.9%) according to the recommended cycle threshold value of