Sustained amygdala response to both novel and newly familiar faces characterizes inhibited temperament
Sustained amygdala response to both novel and newly familiar faces characterizes inhibited temperament
复制标题
DOI：
10.1093/scan/nsq073
复制
发表时间：
2011-10-01
影响因子：
4.2
通讯作者：
Zald, David H.
中科院分区：
文献类型：
--
作者：
Blackford, Jennifer Urbano;Avery, Suzanne N.;Zald, David H.
先前的理论提出，杏仁核在具有抑制性气质的人身上对新异刺激反应过度，抑制性气质是一种基于生物学的倾向，即对新事物表现出谨慎或回避行为。在当前的研究中，我们使用功能性磁共振成像（fMRI）来评估具有极端抑制性或非抑制性气质的人在观看新面孔或近期熟悉的面孔时杏仁核的血氧水平依赖（BOLD）反应。在具有抑制性气质的人中，观看新面孔和近期熟悉的面孔时杏仁核都显示出增强的BOLD反应。相比之下，在具有非抑制性气质的人中，杏仁核的BOLD反应仅在观看新面孔时增强。这些发现表明，抑制性气质的特征并非仅仅是对新面孔的一种简单的过度反应，而是即使面孔已经变得熟悉，杏仁核对面孔的反应仍持续增强。在具有抑制性气质的个体中，这种持续的反应可能与在初次接触之后仍然存在的对社交情境的谨慎有关。
Previous theories have proposed that the amygdala is hyper-responsive to novel stimuli in persons with an inhibited temperament-a biologically based predisposition to respond to novelty with wariness or avoidance behavior. In the current study, we used functional magnetic resonance imaging (fMRI) to assess amygdala blood oxygenation level-dependent (BOLD) response when viewing novel or recently familiarized faces in persons with an extreme inhibited or uninhibited temperament. In persons with an inhibited temperament, the amygdala showed increased BOLD response when viewing both novel and recently familiarized faces. In contrast, in persons with an uninhibited temperament, BOLD response in the amygdala was increased only when viewing novel faces. These findings suggest that inhibited temperament is characterized not by a simple exaggerated response to novel faces, but rather by a sustained increase in amygdala response to faces even after the faces have become familiarized. In individuals with an inhibited temperament, this sustained response may be related to the wariness of social situations that persists beyond initial exposure.