An improved procedure for the three-component synthesis of highly substituted pyridines using ionic liquid
An improved procedure for the three-component synthesis of highly substituted pyridines using ionic liquid
复制标题
DOI：
10.1021/jo070015g
复制
发表时间：
2007-04-13
影响因子：
3.6
通讯作者：
Sowmiah, S.
中科院分区：
文献类型：
--
作者：
Ranu, Brindaban C.;Jana, Ranjan;Sowmiah, S.
一种碱性离子液体，[bmIm]OH，有效地促进了一锅法，三组分缩合醛，丙二腈，和硫酚，以高产率在室温下生产高度取代的吡啶。该反应不涉及任何有害的有机溶剂和有毒催化剂。离子液体被回收并再循环用于后续反应。
A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions.