MACROPHAGE-COLONY STIMULATING FACTOR (M-CSF) IN THE CEREBROSPINAL-FLUID
MACROPHAGE-COLONY STIMULATING FACTOR (M-CSF) IN THE CEREBROSPINAL-FLUID
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DOI：
10.1016/0165-5728(90)90152-d
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发表时间：
1990-09-01
影响因子：
3.3
通讯作者：
TAVOLATO, B
中科院分区：
文献类型：
--
作者：
GALLO, P;PAGNI, S;TAVOLATO, B
在一系列的145例神经系统疾病，巨噬细胞集落刺激因子（M-CSF）检测脑肿瘤，细菌性脑膜炎患者的脑脊液中，很少，艾滋病痴呆综合征。粒细胞集落刺激因子（G-CSF）仅在细菌性脑膜炎患者中发现;粒细胞-巨噬细胞（GM）-CSF从未检测到。这些结果表明，M-CSF可能发挥重要的鞘内免疫调节作用的肿瘤和感染性疾病的中枢神经系统。
In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial meningitis; granulocyte-macrophage (GM)-CSF was never detected. These findings suggest that M-CSF may play an important intrathecal immunoregulatory role in neoplastic and infectious diseases of the central nervous system.