Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood.
Patients with Hypophosphatemic Osteomalacia Need Continuous Treatment during Adulthood.
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DOI：
10.1297/cpe.18.29
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Hasegawa Y
中科院分区：
文献类型：
--
作者：
Suzuki E;Yamada M;Ariyasu D;Izawa M;Miyamoto J;Koto S;Hasegawa Y
儿童低磷血症性佝偻病的治疗包括磷酸盐和维生素D制剂。对于儿童来说，这种方案可以显着改善症状，而针对成人患者的治疗方法尚未确定。因此，我们调查了15例在达到最终身高时停止治疗的成人患者的临床病程，以评估成年后治疗的必要性。13名患者出现症状性并发症，包括骨折。13例患者中，10例重新开始治疗的患者均出现临床改善，未观察到治疗副作用。这项研究表明，有一些低磷酸盐血症性骨软化症患者需要在成年期持续治疗。
The treatment for hypophosphatemic rickets in children includes phosphate and vitamin D preparations. In children, this regimen significantly improves symptoms, while a treatment for adult patients has not been established. We therefore investigated the clinical courses of 15 adult patients who discontinued therapy when final height was achieved in order to assess the necessity of treatment in adulthood. Thirteen patients developed symptomatic complications, including bone fractures. Among the 13, the 10 patients who restarted therapy all showed clinical improvement, and no side effects of treatment were observed. This study shows that there are some patients with hypophosphatemic osteomalacia who need continuous treatment during adulthood.