Diagnosis of Cryptococcosis and Prevention of Cryptococcal Meningitis Using a Novel Point-of-Care Lateral Flow Assay
Diagnosis of Cryptococcosis and Prevention of Cryptococcal Meningitis Using a Novel Point-of-Care Lateral Flow Assay
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DOI：
10.1155/2013/640216
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发表时间：
2013-01-01
影响因子：
0.8
通讯作者：
Dhana, Ashar
中科院分区：
文献类型：
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作者：
Dhana, Ashar
尽管可以获得抗逆转录病毒治疗，但在撒哈拉以南非洲的晚期艾滋病毒感染者中，隐球菌脑膜炎（CM）的死亡率很高。隐球菌抗原（CrAg）可在脑膜炎症状出现前数周至数月出现，可通过筛查预防危及生命的脑膜炎。最近，世界卫生组织推荐一种新的快速igg横向流动“试纸”试验（LFA）用于筛选CD4计数低于100细胞/ μ l的HIV感染者。在本文中，我们描述了两例不同结果的隐球菌病。在第一个病例中，新的CrAg LFA被用作筛检和预防性治疗策略的一部分，以预防CM。在第二个病例中，我们的患者无法获得CrAg LFA，随后发展为危及生命的脑膜炎。据我们所知，这是首例隐球菌病的病例报告诊断使用这种新的化验。
Despite access to antiretroviral therapy, mortality from cryptococcal meningitis (CM) is high among persons with advanced HIV infection in sub- Saharan Africa. Cryptococcal antigen (CrAg) is present several weeks to months before the onset of symptoms of meningitis and can be screened to prevent life threatening meningitis. Recently, theWorld Health Organisation recommended that a new rapid CrAg lateral flow "dipstick" assay (LFA) is to be used to screen HIV- infected persons with CD4 counts of less than 100 cells/mu L. In this paper, we describe two cases of cryptococcosis with differing outcomes. In the first case, the new CrAg LFA was used as part of a screen and preemptive treatment strategy to prevent CM. In the second case, our patient had no access to the CrAg LFA and subsequently developed life threatening meningitis. To the best of our knowledge, this is the first case report of cryptococcosis diagnosed using this novel assay.