RECENT RESULTS ON FUNCTIONAL POLYMERS AND MACROMONOMERS OF INTEREST AS BIOMATERIALS OR FOR BIOMATERIAL MODIFICATION
RECENT RESULTS ON FUNCTIONAL POLYMERS AND MACROMONOMERS OF INTEREST AS BIOMATERIALS OR FOR BIOMATERIAL MODIFICATION
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DOI：
10.1016/0142-9612(94)90275-5
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发表时间：
1994-12-01
期刊：
影响因子：
14
通讯作者：
VERONESE, FM
中科院分区：
文献类型：
--
作者：
FERRUTI, P;RANUCCI, E;VERONESE, FM
不同家族的功能化聚合物与潜在的生物材料，或用于生物材料改性，已被调查。特别是，降解研究已经进行了聚（酰胺基胺），一个家庭的聚合物通过聚加成胺双丙烯酰胺，并赋予肝素络合能力。发现了一些新型的聚酰胺-胺类化合物，它们比传统的聚酰胺-胺类化合物具有更好的抗水解性能。已经研究了衍生自叔氨基官能化的双硫醇与双丙烯酸酯或其它活化的不饱和化合物的加聚的其它叔氨基聚合物。他们的季铵化产物已被证明，在一个平行的工作，作为强大的抗菌剂。通过原位加聚反应，制备了硅橡胶和硅橡胶聚合物的半互穿网络。最后，末端官能化的两亲性低聚物已通过自由基聚合技术制备，并考虑其用于酶修饰。
Different families of functionalized polymers with potential as biomaterials, or for biomaterial modification, have been investigated. In particular, degradation studies have been performed on poly(amidoamines), a family of polymers obtained by polyaddition of amines to bisacrylamides, and endowed with heparin-complexing ability. Some new poly(amidoamines) with more resistance towards hydrolytic degradation than traditional ones have been discovered. Other ter-amino polymers deriving from the polyaddition of ter-amino functionalized bis-thiols to bis-acrylic esters, or other activated unsaturated compounds, have been studied. Their quaternarization products have been proven, in a parallel work, to act as powerful antimicrobial agents. By performing in situ the polyaddition reaction, semi-interpenetrated networks based on silicone rubber and the same polymers have been prepared. Finally, end-functionalized amphiphilic oligomers have been prepared by radical polymerization techniques, and their use for enzyme modification considered.