Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.
Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent.
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DOI：
10.1364/ol.29.002016
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发表时间：
2004-09
期刊：
影响因子：
3.6
通讯作者：
Changhuei Yang;Laura E L McGuckin;J. Simon;M. Choma;B. Applegate;J. Izatt
中科院分区：
文献类型：
--
作者：
Changhuei Yang;Laura E L McGuckin;J. Simon;M. Choma;B. Applegate;J. Izatt
我们报告了一种新的分子对比光学相干断层扫描（MCOCT）实现，通过测量造影剂的光谱微分吸收来描述样品中的造影剂分布。该方法，光谱三角测量MCOCT，可以有效地抑制来自样品的光谱相关散射的贡献，而无需先验的散射特性知识。我们通过绘制54期非洲爪蟾（Xenopus laevis）内吲哚菁绿（一种fda批准的红外红色染料）的分布，展示了这种新的MCOCT模式的分子成像。
We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis.