Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm
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DOI：
10.1016/s0092-8674(00)80334-7
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发表时间：
1997-07-25
期刊：
影响因子：
64.5
通讯作者：
Placzek, M
中科院分区：
文献类型：
--
作者：
Dale, JK;Vesque, C;Placzek, M
中枢神经系统不同吻尾水平的腹中线细胞表现出不同的特性，但共享形成神经管背腹轴的能力。我们在这里表明腹侧中线细胞获得不同的身份，以响应不同的信号活动的基础中胚层。来自脊索前中胚层的信号控制着头端间脑腹侧中线细胞的分化，而脊索则在尾部诱导底板细胞的分化。Sonic hedgehog(SHH)广泛表达于中轴胚层，是间脑腹侧中线细胞和底板诱导所必需的。然而，脊索前中胚层也表达BMP7，BMP7的功能与SHH协调才能诱导吻间脑腹中线鳗鱼。BMP7直接作用于神经细胞，改变它们对SHH的反应，使它们分化为吻侧间脑腹侧中线细胞，而不是底节细胞。我们的结果提出了一种模型，在该模型中，轴向中胚层既诱导了覆盖的神经细胞的分化，又控制了神经管腹侧中线的吻尾特征。
Ventral midline cells at different rostrocaudal levels of the central nervous system exhibit distinct properties but share the ability to pattern the dorsoventral axis of the neural tube. We show here that ventral midline cells acquire distinct identities in response to the different signaling activities of underlying mesoderm. Signals from prechordal mesoderm control the differentiation of rostral diencephalic ventral midline cells, whereas notochord induces floor plate cells caudally. Sonic hedgehog (SHH) is expressed throughout axial mesoderm and is required for the induction of both rostral diencephalic ventral midline cells and floor plate. However, prechordal mesoderm also expresses BMP7 whose function is required coordinately with SHH to induce rostral diencephalic ventral midline eels. BMP7 acts directly on neural cells, modifying their response to SHH so that they differentiate into rostral diencephalic Ventral midline cells rather than floor prate cells. Our results suggest a model whereby axial mesoderm both induces the differentiation of overlying neural cells and controls the rostrocaudal character of the ventral midline of the neural tube.