Electrophysiological Evidence for Different Inhibitory Mechanisms When Stopping or Changing a Planned Response
Electrophysiological Evidence for Different Inhibitory Mechanisms When Stopping or Changing a Planned Response
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DOI：
10.1162/jocn.2010.21573
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发表时间：
2011-09-01
影响因子：
3.2
通讯作者：
Muente, Thomas F.
中科院分区：
文献类型：
--
作者：
Kraemer, Ulrike M.;Knight, Robert T.;Muente, Thomas F.
人们能够通过快速抑制或改变自己的行为来适应不断变化的环境突发事件。反应抑制通常在停止信号范式中进行研究，该范式需要抑制已经准备好的运动反应。对于需要改变运动计划的情况知之甚少，因此必须保留准备好的响应，而必须执行另一个响应。在本研究中，我们研究了电生理学数据是否可以为停止或改变反应时的不同抑制机制提供证据。参与者被要求执行具有两类嵌入式关键试验的选择 RT 任务：停止信号要求抑制任何反应，而改变信号要求参与者抑制准备好的反应并执行另一反应。在这两种条件下，我们观察到刺激处理的差异，表明与成功的抑制相比，失败的反应准备更快。与停止信号试验相反，改变反应不会引起抑制相关的额叶 N2，也不会调节顶叶 mu 功率降低。结果表明，与改变反应相比，当必须抑制反应时，额外的额叶和顶叶区域会参与进来。
People are able to adapt their behavior to changing environmental contingencies by rapidly inhibiting or modifying their actions. Response inhibition is often studied in the stop-signal paradigm that requires the suppression of an already prepared motor response. Less is known about situations calling for a change of motor plans such that the prepared response has to be withheld but another has to be executed instead. In the present study, we investigated whether electrophysiological data can provide evidence for distinct inhibitory mechanisms when stopping or changing a response. Participants were instructed to perform in a choice RT task with two classes of embedded critical trials: Stop signals called for the inhibition of any response, whereas change signals required participants to inhibit the prepared response and execute another one instead. Under both conditions, we observed differences in go-stimulus processing, suggesting a faster response preparation in failed compared with successful inhibitions. In contrast to stop-signal trials, changing a response did not elicit the inhibition-related frontal N2 and did not modulate the parietal mu power decrease. The results suggest that compared with changing a response, additional frontal and parietal regions are engaged when having to inhibit a response.