Probucol decreases apolipoprotein A-I transport rate and increases high density lipoprotein cholesteryl ester fractional catabolic rate in control and human apolipoprotein A-I transgenic mice.
Probucol decreases apolipoprotein A-I transport rate and increases high density lipoprotein cholesteryl ester fractional catabolic rate in control and human apolipoprotein A-I transgenic mice.
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在对照和人载脂蛋白 A-I 转基因小鼠中，普罗布考可降低载脂蛋白 A-I 转运速率并增加高密度脂蛋白胆固醇酯分解代谢率。
DOI：
10.1161/01.atv.11.5.1295
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Breslow,JL
中科院分区：
文献类型：
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作者：
Hayek,T;Chajek-Shaul,T;Walsh,A;Azrolan,N;Breslow,JL
在对照和人载脂蛋白a - 1转基因（huitg）小鼠中测定普罗布考对脂蛋白代谢的影响。在对照小鼠中，普罗布考通过将高密度脂蛋白（HDL）胆固醇从46 +/- 20降低到14 +/- 1 mg/dl，将总胆固醇从67 +/- 2降低到25 +/- 2 mg/dl，将低密度脂蛋白（LDL）胆固醇从11 +/- 1降低到5 +/- 1 mg/dl。载脂蛋白（apo） A-I水平从122 +/- 8降至56 +/- 5 mg/dl。在huitg小鼠中，probucol将总胆固醇从121 +/- 5降低到77 +/- 3 mg/dl，将HDL胆固醇从84 +/- 4降低到56 +/- 3 mg/dl，将LDL胆固醇从19 +/- 2降低到11 +/- 2 mg/dl。人类载脂蛋白A-I水平从267 +/- 13降至144 +/- 12 mg/dl，小鼠载脂蛋白A-I水平从18 +/- 2降至9 +/- 2 mg/dl。对照动物主要是单分散的高密度脂蛋白，颗粒直径为10纳米。普罗布考似乎没有改变对照动物的颗粒大小分布。小鼠高密度脂蛋白多分散，粒径分别为10.1和8.5 nm。普罗布考处理导致这些动物的HDL颗粒直径为9.4和8.5 nm，明显减小了较大颗粒的大小。体内代谢研究表明，载脂蛋白a - i的减少主要是由于运输速率的降低，而高密度脂蛋白胆固醇的降低主要是由于高密度脂蛋白胆固醇酯分解代谢率的增加。（摘要删节250字）
Probucol effects on lipoprotein metabolism were determined in control and human apolipoprotein A-I transgenic (HuAITg) mice. In control mice, probucol reduced total cholesterol from 67 +/- 2 to 25 +/- 2 mg/dl by reducing high density lipoprotein (HDL) cholesterol from 46 +/- 20 to 14 +/- 1 mg/dl and low density lipoprotein (LDL) cholesterol from 11 +/- 1 to 5 +/- 1 mg/dl. Apolipoprotein (apo) A-I levels were reduced from 122 +/- 8 to 56 +/- 5 mg/dl. In HuAITg mice, probucol reduced total cholesterol from 121 +/- 5 to 77 +/- 3 mg/dl by reducing HDL cholesterol from 84 +/- 4 to 56 +/- 3 mg/dl and LDL cholesterol from 19 +/- 2 to 11 +/- 2 mg/dl. Human apo A-I levels were reduced from 267 +/- 13 to 144 +/- 12 mg/dl and mouse apo A-I levels from 18 +/- 2 to 9 +/- 2 mg/dl. Control animals have primarily a monodisperse HDL with a particle diameter of 10 nm. Probucol did not appear to change the particle size distribution in the control animals. The HuAITg mice have a polydisperse HDL with particle diameters of 10.1 and 8.5 nm. Probucol treatment of these animals resulted in HDL with particle diameters of 9.4 and 8.5 nm, apparently reducing the size of the larger particles. In vivo turnover studies revealed that the reduction in apo A-I was primarily due to a decrease in transport rate, whereas the reduction in HDL cholesterol was primarily due to an increase in HDL cholesteryl ester fractional catabolic rate.(ABSTRACT TRUNCATED AT 250 WORDS)