Regulation of feeding by galnon
Regulation of feeding by galnon
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DOI：
10.1016/j.npep.2004.01.001
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发表时间：
2004-02-01
期刊：
影响因子：
2.9
通讯作者：
Langel, Ü
中科院分区：
文献类型：
--
作者：
Abramov, U;Florén, A;Langel, Ü
Galanin is a neuropeptide that has been implicated in multiple bioactivities, inter alia eating disorders. In this study, we have examined the effects of galnon, a novel low molecular weight galanin receptor ligand. Previous studies have shown that galnon acts as a systemically active, blood-brain barrier crossing agonist on galanin signaling both in vitro and in vivo, inhibiting pentylenetetrazole-induced seizures. Here, intracerebroventricular (10-20 mug) and intraperitoneal (1.5-5 mg/kg) administration of galnon induced a strong, dose-dependent reduction of food intake in rats and mice. This reduction in feeding occurred without reducing general activity and was shown to be attenuated by an intracerebroventricular administration of M35, a peptide galanin antagonist. These data demonstrate that galnon is a promising tool for studies of the involvement of galanin in feeding disorders and other behavioral processes. (C) 2004 Elsevier Ltd. All rights reserved.
