Consequences of cytoplasmic irradiation: studies from microbeam.
Consequences of cytoplasmic irradiation: studies from microbeam.
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DOI:
10.1269/jrr.08120s
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发表时间:
2009-03
影响因子:
2
通讯作者:
Hei TK
中科院分区:
文献类型:
--
作者:
Zhou H;Hong M;Chai Y;Hei TK
The prevailing dogma for radiation biology is that genotoxic effects of ionizing radiation such as mutations and carcinogenesis are attributed mainly to direct damage to the nucleus. However, with the development of microbeam that can target precise positions inside the cells, accumulating evidences have shown that energy deposit by radiation in nuclear DNA is not required to trigger the damage, extra-nuclear or extra-cellular radiation could induce the similar biological effects as well. This review will summarize the biological responses after cytoplasm irradiated by microbeam, and the possible mechanisms involved in cytoplasmic irradiation.
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