Consequences of cytoplasmic irradiation: studies from microbeam.

Consequences of cytoplasmic irradiation: studies from microbeam.
复制标题

DOI:
10.1269/jrr.08120s
复制
发表时间:
2009-03
影响因子:
2
通讯作者:
Hei TK
Hei TK
中科院分区:
医学4区
文献类型:
--
作者:
Zhou H;Hong M;Chai Y;Hei TK

文献摘要

参考文献

被引文献

相似文献

辐射生物学的普遍教条是,电离辐射的遗传毒性效应,如突变和致癌作用,主要归因于对细胞核的直接损害。然而,随着微束技术的发展,微束可以精确定位于细胞内,越来越多的证据表明,辐射能量存款在细胞核DNA中并不需要触发损伤,核外或细胞外辐射也可以引起类似的生物学效应。本文就微束辐照细胞质后的生物学效应及其可能的机制作一综述。
The prevailing dogma for radiation biology is that genotoxic effects of ionizing radiation such as mutations and carcinogenesis are attributed mainly to direct damage to the nucleus. However, with the development of microbeam that can target precise positions inside the cells, accumulating evidences have shown that energy deposit by radiation in nuclear DNA is not required to trigger the damage, extra-nuclear or extra-cellular radiation could induce the similar biological effects as well. This review will summarize the biological responses after cytoplasm irradiated by microbeam, and the possible mechanisms involved in cytoplasmic irradiation.
DOI: 10.1073/pnas.94.8.3765
发表时间: 1997-04-15
影响因子: 11.1
作者:
Hei, TK;Wu, LJ;RandersPehrson, G
通讯作者: RandersPehrson, G
DOI: 10.1667/0033-7587(2001)155
发表时间: 2001-01-01
期刊: RADIATION RESEARCH
影响因子: 3.4
作者:
Chang, CC;Sun, W;Trosko, JE
通讯作者: Trosko, JE
DOI: 10.1038/sj.onc.1209863
发表时间: 2007-02-01
期刊: ONCOGENE
影响因子: 8
作者:
Burdak-Rothkamm, S.;Short, S. C.;Prise, K. M.
通讯作者: Prise, K. M.
DOI: 10.1007/s11064-007-9380-3
发表时间: 2007-11-01
影响因子: 4.4
作者:
Isaac, Alfred Orina;Dukhande, Vikas V.;Lai, James C. K.
通讯作者: Lai, James C. K.