STUDIES OF GENETIC-FACTORS IN PROSTATE-CANCER IN A TWIN POPULATION
STUDIES OF GENETIC-FACTORS IN PROSTATE-CANCER IN A TWIN POPULATION
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DOI：
10.1016/s0022-5347(17)32452-7
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发表时间：
1994-11-01
影响因子：
6.6
通讯作者：
DAMBER, JE
中科院分区：
文献类型：
--
作者：
GRONBERG, H;DAMBER, L;DAMBER, JE
有证据表明，阳性家族史是前列腺癌发生的危险因素。前列腺癌的家族聚集性可能提示遗传因素在该病的病因学中起重要作用。为了进一步阐明遗传因素的相对重要性，我们研究了一对瑞典双胞胎中的前列腺癌。使用瑞典双胞胎登记处和瑞典癌症登记处的信息。在1959年至1989年期间，在4,840对男性双胞胎中发现了458例前列腺癌。其中16对同卵双生子和6对异卵双生子与前列腺癌的诊断一致。同卵和异卵的前带一致率分别为0.192和0.043，易感性相关系数分别为0.40和-0.05。这些差异的先证者一致率和相关性的责任单卵对相比，双卵对是明显的。结果表明，遗传因素可能是重要的前列腺癌的发展。本研究的结果表明，需要进一步调查的遗传因素在前列腺癌，包括大规模的流行病学研究和调查的分子遗传学的风险家庭。
It has been suggested that positive family history constitutes a risk factor for the development of prostate cancer. Familial clustering of prostate cancer might suggest that genetic factors are of importance in the etiology of this disease. To elucidate further the relative importance of genetic factors, we studied prostate cancer among an unselected Swedish twin population. Information from the Swedish Twin Registry and the Swedish Cancer Registry was used. In 4,840 male twin pairs 458 prostate cancers were identified between 1959 and 1989. Among these 16 monozygotic and 6 dizygotic twin pairs were concordant for prostate cancer. Proband concordance rates of 0.192 and 0.043, and a correlation of liability of 0.40 and -0.05 were found for monozygotic and dizygotic pairs, respectively. These differences in proband concordance rates and correlations of liability for monozygotic pairs compared to dizygotic pairs are pronounced. The results indicate that genetic factors might be of importance for the development of prostate cancer. The results of this study indicate the need for further investigations of genetic factors in prostate cancer, including large scale epidemiological studies and investigations of molecular genetics of risk families.