Cell therapies for traumatic brain injury
Cell therapies for traumatic brain injury
复制标题
DOI：
10.3171/foc/2008/24/3-4/e17
复制
发表时间：
2008-03-01
影响因子：
4.1
通讯作者：
Cox, Charles S.
中科院分区：
文献类型：
--
作者：
Harting, Matthew T.;Baumgartner, James E.;Cox, Charles S.
细胞疗法功效的初步发现目前正在转化为临床试验。虽然大量的工作集中在细胞治疗应用于各种疾病，包括心脏病，骨病，肝病和癌症，但人们仍然非常期待干细胞将推进目前急性神经系统疾病的治疗方案。创伤性脑损伤是一种破坏性事件，目前的治疗方法有限。在这份报告中，作者讨论了使用成体干细胞治疗创伤性脑损伤的现状，包括基本细胞类型和潜在的作用机制，临床前数据和临床试验的启动。
Preliminary discoveries of the efficacy of cell therapy are currently being translated to clinical trials. Whereas a significant amount of work has been focused on cell therapy applications for a wide array of diseases, including cardiac disease, bone disease, hepatic disease, and cancer, there continues to be extraordinary anticipation that stem cells will advance the current therapeutic regimen for acute neurological disease. Traumatic brain injury is a devastating event for which current therapies are limited. In this report the authors discuss the current status of using adult stem cells to treat traumatic brain injury, including the basic cell types and potential mechanisms of action, preclinical data, and the initiation of clinical trials.