17β-hydroxy steroid dehydrogenases in human endometrium and its disorders
17β-hydroxy steroid dehydrogenases in human endometrium and its disorders
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DOI：
10.1016/j.mce.2005.11.038
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发表时间：
2006-03-27
影响因子：
4.1
通讯作者：
Sasano, H
中科院分区：
文献类型：
--
作者：
Ito, K;Utsunomiya, H;Sasano, H
原位雌激素代谢和合成被认为在子宫内膜癌的发生和发展中起着非常重要的作用。17 β-羟基类固醇脱氢酶（17-HSDs）是参与活性性类固醇（包括睾酮、雌酮（E1）和雌二醇（E2））形成的酶。雌激素由两种酶，17-HSD 1型和2型互换，1型将E1转化为E2，而2型则起相反的作用。17-HSD 5型催化雄烯二酮还原为睾酮。17-HSD 2型在正常子宫内膜、子宫内膜增生症和子宫内膜癌中的表达相应降低。子宫内膜癌组织中E2浓度与17-HSD 2型mRNA水平呈负相关。17-HSD 5型在正常子宫内膜、子宫内膜增生症和子宫内膜癌中的表达均明显增高。这些结果表明，17-HSD 2型和5型在子宫内膜癌原位雌激素产生的调节中起重要作用。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
In situ estrogen metabolism and synthesis have been considered to play a very important role in the development and progression of human endometrial carcinoma.17 beta-Hydroxysteroid dehydrogenases (17-HSDs) are enzymes involved in the formation of active sex steroids, including testosterone, estrone (E1) and estradiol (E2). Estrogens are interchanged by two enzymes, 17-HSD types 1 and 2, type 1 converts E1 to E2, and type 2 does reverse actions. 17-HSD type 5 catalyzes the reduction of androstenedione to testosterone. 17-HSD type 2 expression was decreased through normal endometrium, hyperplasia and carcinoma accordingly. There was a significant inverse correlation between intratumoral E2 concentration and the level of 17-HSD type 2 mRNA in endometrial carcinoma. 17-HSD type 5 expression was significantly increased through normal endometrium, hyperplasia and carcinoma accordingly. These results indicated that 17-HSD types 2 and 5 play an important role in the regulation of in situ estrogen production in endometrial carcinoma. (c) 2005 Elsevier Ireland Ltd. All rights reserved.