PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis - Relation to environmental and genetic determinants
PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis - Relation to environmental and genetic determinants
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DOI：
10.1161/01.atv.18.4.562
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发表时间：
1998-04-01
影响因子：
8.7
通讯作者：
Di Minno, G
中科院分区：
文献类型：
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作者：
Margaglione, M;Cappucci, G;Di Minno, G
纤溶酶原激活物抑制物-1(PAI-1)的血浆水平一直与PAI-1基因的4G/5G多态性相关。肾素-血管紧张素途径在调节PAI-1血浆水平中起作用。血管紧张素转换酶(ACE)基因的插入(I)/缺失(D)多态性与血浆和细胞ACE水平有关。在意大利南部一家医院的1032名员工(男性446名，女性586名；年龄22-66岁)中，我们调查了PAI-1 4G/5G与ACE I/D基因变异和血浆PAI-1抗原水平的关系。单因素分析显示，男性PAI-1水平显著高于男性(P
Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. The renin-angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been related to plasma and cellular ACE levels. In 1032 employees (446 men and 586 women; 22 to 66 years old) of a hospital in southern Italy, we investigated the association between PAI-1 4G/5G and the ACE I/D gene variants and plasma PAI-1 antigen levels. None of the individuals enrolled had clinical evidence of atherosclerosis, In univariate analysis, PAI-1 levels were significantly higher in men (P