Essential components for a glutamatergic synapse between Merkel cell and nerve terminal in rats
Essential components for a glutamatergic synapse between Merkel cell and nerve terminal in rats
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DOI：
10.1016/j.neulet.2004.02.071
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发表时间：
2004-05-27
影响因子：
2.5
通讯作者：
Cahusac, PMB
中科院分区：
文献类型：
--
作者：
Hitchcock, IS;Genever, PG;Cahusac, PMB
默克尔细胞的确切作用及其可能参与机械感觉尚不清楚。本研究的目的是确定，在成年大鼠窦毛囊中，参与神经递质释放的一些囊泡蛋白的表达模式，以提供一个更清晰的理解默克尔细胞信号传导机制。我们确定了显着的表达和共定位的促甲状腺激素能囊泡装载蛋白VGLUT 1和VGLUT 2的网站上的窦毛囊已知是密集的默克尔细胞。我们还发现，在同一区域的毛囊囊泡回收蛋白synaptogyrin和syntaxin-6的表达。我们的数据表明，谷氨酸信号参与了默克尔细胞的机械感觉和囊泡贩运是常见的默克尔细胞-神经突复合体。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
The exact role of Merkel cells and their possible involvement in mechanosensation is unclear. The aim of this study was to determine, in the adult rat sinus hair follicle, the expression pattern of a number of vesicular proteins involved in neurotransmitter release to provide a clearer understanding of Merkel cell signalling mechanisms. We identified prominent expression and co-localization of the glutamatergic vesicle loading proteins VGLUT1 and VGLUT2 at the site of the sinus hair follicle known to be densely populated with Merkel cells. We also found expression of the vesicle recycling proteins synaptogyrin and syntaxin-6 in the same region of the hair follicle. Our data suggest that glutamate signalling is involved in Merkel cell mechanosensation and that vesicular trafficking is commonplace in the Merkel cell-neurite complex. (C) 2004 Elsevier Ireland Ltd. All rights reserved.