PERIPHERAL VASCULAR-RESPONSES TO HYPERTHERMIA IN THE RAT
PERIPHERAL VASCULAR-RESPONSES TO HYPERTHERMIA IN THE RAT
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DOI：
10.1152/jappl.1988.64.6.2582
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发表时间：
1988-06-01
影响因子：
3.3
通讯作者：
GISOLFI, CV
中科院分区：
文献类型：
--
作者：
KREGEL, KC;WALL, PT;GISOLFI, CV
为了研究中暑前驱期外周血管反应的顺序和性质，在大鼠肠系膜上动脉（SMA）、左髂动脉（LIA）或左肾动脉（LRA）和尾外动脉（ECA）上植入多普勒血流探头。研究在未麻醉的大鼠（n = 6）暴露于46度。40℃时氯氯麻醉动物（n = 11）。C.还监测了核心（Tc）和尾部皮肤温度、心率和平均动脉血压（MAP）。在两组中，长时间（70-150分钟）暴露使Tc从37.0℃逐渐升高到44.0℃。当温度超过41.5度时，MAP上升到一个平台，然后急剧下降。C.在加热的早期阶段，SMA电阻增加，在MAP急剧下降之前的10-15分钟从这个升高的水平急剧下降。ECA电阻初期下降，但在加热末期上升。在未麻醉的动物中，LIA抵抗逐渐下降。氯氯蔗糖麻醉后，LRA抗性逐渐升高，当Tc超过41.5℃时，LRA抗性明显升高。C.这些数据支持这样的假设，即代偿性内脏血管收缩的选择性丧失可能引发一系列具有中暑特征的事件。这种不同的血管反应在未麻醉和麻醉的动物中是相似的。
To investigate the sequence and nature of the peripheral vascular responses during the prodromal period of heat stroke, rats were implanted with Doppler flow probes on the superior mesenteric (SMA), left iliac (LIA) or left renal (LRA), and external caudal (ECA) arteries. Studies were performed in unanesthetized rats (n = 6) exposed to 46.degree. C and in chloralose-anesthetized animals (n = 11) at 40.degree. C. Core (Tc) and tail-skin temperatures, heart rate, and mean arterial blood pressure (MAP) were also monitored. In both groups, prolonged (70-150 min) exposure progressively elevated Tc from 37.0 to 44.0.degree.C. MAP rose to a plateau then fell precipitously as Tc exceeded 41.5.degree. C. SMA resistance increased throughout the early stages of heating, with a sharp decline from this elevated level 10-15 min before the precipitous fall in MAP. ECA resistance fell initially but increased in the terminal stage of heating. In unanesthetized animals, LIA resistance progressively declined. In chloralose-anesthetized animals LRA resistance rose progressively, then increased markedly as Tc exceeded 41.5.degree. C. These data support the hypothesis that a selective loss of compensatory splanchnic vasoconstriction may trigger the cascade of events that characterize heat stroke. This differential vascular response was similar in both unanesthetized and anesthetized animals.