LESS BODY-FAT ACCUMULATION IN RATS FED A SAFFLOWER OIL DIET THAN IN RATS FED A BEEF TALLOW DIET
LESS BODY-FAT ACCUMULATION IN RATS FED A SAFFLOWER OIL DIET THAN IN RATS FED A BEEF TALLOW DIET
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DOI：
10.1093/jn/120.11.1291
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发表时间：
1990-11-01
影响因子：
4.2
通讯作者：
SUZUKI, M
中科院分区：
文献类型：
--
作者：
SHIMOMURA, Y;TAMURA, T;SUZUKI, M
研究了长期饲喂不同脂肪酸组成的高脂饲料对大鼠体脂肪蓄积的影响。以红花油或牛脂为基础的等能量饲料喂养大鼠4mo。在整个实验期间，每种饮食都是每天新鲜准备的。在实验的第50~54天，测定餐后6h的氧耗量和二氧化碳生成量。红花油组大鼠餐后3h耗氧量明显高于牛油组，提示前者饮食诱导的生热作用更强。从呼吸商的评估来看，前者的脂肪氧化率也较高。试验期结束后(4mo)，红花油组大鼠体内脂肪蓄积明显减少。这种差异至少在一定程度上归因于饮食诱导的产热和脂肪氧化增加。饲喂红花油的大鼠血清三酰甘油水平明显低于饲喂牛脂的大鼠。餐后心脏和比目鱼肌脂蛋白脂酶活性前者高于后者。这些结果表明，摄入红花油可提高心肌和骨骼肌脂蛋白脂酶活性，从而提高脂肪氧化率，降低血清三酰甘油水平。
The effects on body fat accumulation of long-term feeding of high fat diets of differing fatty acid composition were studied in rats. The rats were meal-fed isoenergetic diets based on safflower oil or beef tallow for 4 mo. Each diet was freshly prepared every day throughout the experimental period. Oxygen consumption and carbon dioxide production for 6 h after meals were measured between the 50th and 54th d of the experimental period. Oxygen consumption for 3 h after meals was significantly greater in the safflower oil diet group than in the beef tallow diet group, indicating greater diet-induced thermogenesis in the former group. From the assessment of respiratory quotient, the fat oxidation rate was also higher in the former. After the experimental period (4 mo), body fat accumulation was significantly less in the rats fed safflower oil. This difference was, at least in part, ascribed to increased diet-induced thermogenesis and fat oxidation. Serum triacylglycerol level was markedly lower in the rats fed safflower oil than in those fed beef tallow. The lipoprotein lipase activities in heart and soleus muscles after meals appeared to be higher in the former than in the latter. These results suggest that the consumption of the safflower oil diet increased lipoprotein lipase activity in heart and skeletal muscle, resulting in the elevation of fat oxidation rate and the depression of serum triacylglycerol level.