Dental biofilm: ecological interactions in health and disease
Dental biofilm: ecological interactions in health and disease
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DOI：
10.1111/jcpe.12679
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发表时间：
2017-03-01
影响因子：
6.7
通讯作者：
Zaura, Egija
中科院分区：
文献类型：
--
作者：
Marsh, P. D.;Zaura, Egija
背景资料：口腔微生物组是多样的，存在于口腔表面的结构和功能组织biofilms. Aim：描述网络的微生物相互作用（包括协同和拮抗）发生在这些biofilms和评估其在口腔健康和牙科diseases.Methods的作用：PubMed数据库中检索的研究微生物生态相互作用在牙科biofilms。检索结果不适合自己的系统评价，并已总结在一个叙述review.Results：547原始研究文章和212评论确定。大多数（86%）研究文章涉及细菌-细菌相互作用，而王国间微生物相互作用研究最少。的相互作用包括物理和营养的协同协会，拮抗作用，细胞与细胞的通信和基因transfer.Conclusions：口腔微生物群落显示紧急属性，不能推断从单一物种的研究。单个生物体生长在它们不能在纯培养物中容忍的环境中。多重协同和拮抗相互作用的网络产生微生物的相互依赖性，并使生物膜对微小的环境扰动具有弹性，这有助于口腔健康。如果关键的环境压力超过与健康相关的阈值，那么口腔微生物之间的竞争力就会改变，生态失调就会发生，增加牙齿疾病的风险。
Background: The oral microbiome is diverse and exists as multispecies microbial communities on oral surfaces in structurally and functionally organized biofilms.Aim: To describe the network of microbial interactions (both synergistic and antagonistic) occurring within these biofilms and assess their role in oral health and dental disease.Methods: PubMed database was searched for studies on microbial ecological interactions in dental biofilms. The search results did not lend themselves to systematic review and have been summarized in a narrative review instead.Results: Five hundred and forty-seven original research articles and 212 reviews were identified. The majority (86%) of research articles addressed bacterial-bacterial interactions, while inter-kingdom microbial interactions were the least studied. The interactions included physical and nutritional synergistic associations, antagonism, cell-to-cell communication and gene transfer.Conclusions: Oral microbial communities display emergent properties that cannot be inferred from studies of single species. Individual organisms grow in environments they would not tolerate in pure culture. The networks of multiple synergistic and antagonistic interactions generate microbial inter-dependencies and give biofilms a resilience to minor environmental perturbations, and this contributes to oral health. If key environmental pressures exceed thresholds associated with health, then the competitiveness among oral microorganisms is altered and dysbiosis can occur, increasing the risk of dental disease.