Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons.
Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons.
复制标题
在有意识的狒狒中，短期冠状动脉闭塞后，肌酸激酶的释放与心肌坏死无关。
DOI：
10.1016/s0735-1097(85)80216-3
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发表时间：
1985
影响因子：
24
通讯作者：
Vatner,SF
中科院分区：
文献类型：
--
作者：
Heyndrickx,GR;Amano,J;Kenna,T;Fallon,JT;Patrick,TA;Manders,WT;Rogers,GG;Rosendorff,C;Vatner,SF
研究了冠状动脉闭塞15分钟对血浆肌酸激酶（CK）和CK- mb同工酶活性、局部心肌功能和随后心肌坏死的影响。左中冠状动脉前降支闭塞导致收缩期壁增厚完全丧失（超声传递时间技术），心外膜（-93%）和心内膜（-96%）血流减少（微球技术）。15分钟后再灌注，24小时后区域功能完全恢复。一系列血浆酶活性显示总CK从71±11显著增加到976±158 U/l， CK- mb从低到无法测量的水平显著增加到21.4±2.9 U/l。在尸检中，既没有观察到大体病理证据（三苯四唑氯化染色技术），也没有观察到心肌坏死的组织学证据。因此，在没有细胞坏死的情况下，有意识的狒狒心肌缺血的短暂发作与血液中CK和CK- mb的显著出现有关。
The effects of 15 minute periods of coronary artery occlusion on plasma creatine kinase (CK) and CK-MB isoenzyme activity, regional myocardial function and subsequent myocardial necrosis were studied in six conscious baboons 2 to 3 weeks after recovery from instrumentation. Mid left anterior descending coronary artery occlusion induced complete loss of systolic wall thickening (ultrasound transit time technique) and decreases in epicardial (-93%) and endocardial (-96%) blood flows (microsphere technique). Reperfusion after 15 minutes resulted in complete recovery of regional function 24 hours later.Serial plasma enzyme activity revealed a significant increase in total CK from 71 ± 11 to 976 ± 158 U/liter and in CK-MB from levels that were too low to measure to 21.4 ± 2.9 U/liter. At autopsy, neither gross pathologic evidence (triphenyltetrazolium chloride staining technique) nor histologic evidence of myocardial necrosis was observed. Thus, in the conscious baboon short episodes of myocardial ischemia are associated with a significant appearance of CK and CK-MB in the blood in the absence of cellular necrosis.