Diurnal growth hormone and glucose abnormalities in unstable diabetics: studies of ambulatory-fed subjects during continuous blood glucose analysis.
Diurnal growth hormone and glucose abnormalities in unstable diabetics: studies of ambulatory-fed subjects during continuous blood glucose analysis.
复制标题
不稳定糖尿病患者的昼夜生长激素和血糖异常：连续血糖分析期间流动喂养受试者的研究。
DOI：
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发表时间：
1972
影响因子：
5.8
通讯作者：
V. Fatourechi
中科院分区：
文献类型：
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作者：
G. Molnar;W. Taylor;A. Langworthy;V. Fatourechi
在标准化非卧床进食条件下（延长最佳治疗准备后的48小时研究期），连续监测血糖（BG），每小时测定一次血浆生长激素（hGH）。根据血糖波动的平均幅度（法师，一种日内BG变异性的测量）、连续几天匹配BG值的每日差异的平均值（MODD，一种日间BG变异性的测量）和平均BG（MBG，一种昼夜血糖的测量）来量化BG调节稳定性。8例不稳定型糖尿病患者，均具有高血糖参数，与3例稳定型糖尿病患者和3例正常受试者相比，平均每小时hGH和峰值hGH值也较高。虽然意外的低血糖发作以及与血压和睡眠相关的hGH升高导致不稳定型糖尿病患者的hGH水平较高，但这些事件均不能解释观察到的差异。在这项研究中，糖尿病不稳定性和性别被发现产生显着影响。对私...
Blood glucose (BG) was monitored continuously and plasma growth hormone (hGH) was determined at hourly intervals in patients under standardized ambulatory-fed conditions (48-hr study periods after prolonged preparation for optimal therapy). BG regulatory stability was quantified on the basis of mean amplitude of glycemic excursions (MAGE, a measure of withinday BG variability), mean of daily differences of matched BG values on successive days (MODD, a measure of between-day BG variability), and mean BG (MBG, a measure of diurnal glycemia). Eight unstable diabetics, all with high BG parameters, also had high mean hourly hGH and peak hGH values compared with three stable diabetics and three normal subjects. While inadvertent hypoglycemic episodes and rcise-related and sleep-related hGH increases contributed to the higher hGH levels in the unstable diabetics, none of these events accounted for the observed differences. In this study, diabetic instability and sex were found to exert significant effects. At th...